University of Colorado, School of Medicine, Aurora, CO.
Currently, New York Presbyterian Hospital-Columbia University, New York, NY.
J Acquir Immune Defic Syndr. 2020 Jun 1;84(2):228-233. doi: 10.1097/QAI.0000000000002326.
People with HIV (PWH) may have lower daily activity levels compared with persons without HIV. We sought to determine the impact of initiating a supervised exercise program on the daily step count of sedentary PWH and uninfected controls.
PWH and controls, aged 50-75, were enrolled in a 24-week supervised exercise program. All individuals were given a pedometer and instructed in regular use. A linear mixed model taking into account random effects was used to model daily step count.
Of 69 participants that began the study, 55 completed and 38 (21 PWH, 17 controls) had complete pedometer data. Baseline daily step count on nonsupervised exercise day was (estimated geometric mean, 95% confidence interval) 3543 (1306 to 9099) for PWH and 4182 (1632 to 10,187) for controls. Both groups increased daily steps on supervised [43% (20 to 69)%, P < 0.001] but not unsupervised exercise days [-12% (-24 to 1)%, P = 0.071]. Compared with controls, PWH had 26% [(-47 to 4)%, P = 0.08] fewer daily steps on days with supervised exercise and 35% [-53 to -10)%, P = 0.011] fewer daily steps on days without supervised exercise. Higher body mass index (per 1 unit) and smoking were associated with fewer daily steps [-5% (-9 to -1)%; -49% (-67 to -23)%; P ≤ 0.012]. Days with precipitation [-8% (-13 to -3)%, P = 0.002] or below freezing [-10% [-15 to -4)%, P < 0.001] were associated with fewer steps.
Supervised exercise increased daily step counts in sedentary individuals, but at the expense of fewer steps on nonsupervised exercise days.
与未感染 HIV 的人相比，HIV 感染者（PWH）的日常活动水平可能较低。我们旨在确定启动监督下的锻炼计划对久坐的 PWH 和未感染对照者的日常步数的影响。
50-75 岁的 PWH 和对照者入组参加 24 周的监督锻炼计划。所有参与者都被发放计步器并接受常规使用指导。采用考虑随机效应的线性混合模型来对日常步数进行建模。
在开始研究的 69 名参与者中，有 55 名完成了研究，其中 38 名（21 名 PWH，17 名对照者）有完整的计步器数据。监督下非运动日的基础日常步数（估计的几何平均值，95%置信区间）为 PWH 组 3543（1306 至 9099），对照组 4182（1632 至 10187）。两组在监督下的日常步数均增加[43%（20 至 69）%，P<0.001]，而非监督下的日常步数则无增加[-12%（-24 至 1）%，P=0.071]。与对照组相比，PWH 在有监督运动日的日常步数少 26%[（-47 至 4）%，P=0.08]，在无监督运动日的日常步数少 35%[（-53 至 -10）%，P=0.011]。更高的体重指数（每增加 1 个单位）和吸烟与日常步数减少相关[-5%（-9 至 -1）%；-49%（-67 至 -23）%；P≤0.012]。有降水[-8%（-13 至 -3）%，P=0.002]或低于冰点[-10%（-15 至 -4）%，P<0.001]的日子与日常步数减少相关。
监督下的锻炼增加了久坐个体的日常步数，但以牺牲非监督运动日的日常步数为代价。
