尼索地平对地高辛血流动力学效应及血浆浓度的影响。
Influence of nisoldipine on haemodynamic effects and plasma levels of digoxin.
作者信息
Kirch W, Stenzel J, Dylewicz P, Hutt H J, Santos S R, Ohnhaus E E
出版信息
Br J Clin Pharmacol. 1986 Aug;22(2):155-9. doi: 10.1111/j.1365-2125.1986.tb05243.x.
Abstract
In a placebo controlled double-blind study including 10 patients with heart failure the nisoldipine/digoxin interaction was studied. Nisoldipine was shown to elevate digoxin plasma concentrations significantly by about 15% (trough levels). During chronic combination therapy with nisoldipine trough levels and plasma concentrations 4 h after the morning dose of digoxin were 1.35 +/- 0.14 and 1.92 +/- 0.16 ng ml-1 respectively, whereas they averaged to 1.16 +/- 0.14 and 1.52 +/- 0.16 ng ml-1 with digoxin and placebo (P less than 0.05; mean +/- s.e. mean). Systolic time intervals were significantly altered by nisoldipine co-administration compared with digoxin plus placebo. In certain patients the elevation of digoxin plasma levels due to nisoldipine co-administration could be of clinical relevance.
摘要
在一项纳入10例心力衰竭患者的安慰剂对照双盲研究中，对尼索地平与地高辛的相互作用进行了研究。结果显示，尼索地平可使地高辛血浆浓度显著升高约15%（谷浓度）。在与尼索地平的慢性联合治疗期间，地高辛晨服剂量后4小时的谷浓度和血浆浓度分别为1.35±0.14和1.92±0.16 ng/ml，而地高辛与安慰剂联合治疗时平均为1.16±0.14和1.52±0.16 ng/ml（P<0.05；均值±标准误均值）。与地高辛加安慰剂相比，联合使用尼索地平显著改变了收缩期时间间期。在某些患者中，联合使用尼索地平导致地高辛血浆水平升高可能具有临床意义。
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