Radiography and Diagnostic Imaging, School of Medicine, University College Dublin, Belfield, Dublin 4, Ireland.
COCIR, Brussels, Belgium.
J Transl Med. 2022 Mar 18;20(1):137. doi: 10.1186/s12967-022-03344-4.
Medical applications of ionising radiation and associated radiation protection research often encounter long delays and inconsistent implementation when translated into clinical practice. A coordinated effort is needed to analyse the research needs for innovation transfer in radiation-based high-quality healthcare across Europe which can inform the development of an innovation transfer framework tailored for equitable implementation of radiation research at scale.
Between March and September 2021 a Delphi methodology was employed to gain consensus on key translational challenges from a range of professional stakeholders. A total of three Delphi rounds were conducted using a series of electronic surveys comprised of open-ended and closed-type questions. The surveys were disseminated via the EURAMED Rocc-n-Roll consortium network and prominent medical societies in the field. Approximately 350 professionals were invited to participate. Participants' level of agreement with each generated statement was captured using a 6-point Likert scale. Consensus was defined as median ≥ 4 with ≥ 60% of responses in the upper tertile of the scale. Additionally, the stability of responses across rounds was assessed.
In the first Delphi round a multidisciplinary panel of 20 generated 127 unique statements. The second and third Delphi rounds recruited a broader sample of 130 individuals to rate the extent to which they agreed with each statement as a key translational challenge. A total of 60 consensus statements resulted from the iterative Delphi process of which 55 demonstrated good stability. Ten statements were identified as high priority challenges with ≥ 80% of statement ratings either 'Agree' or 'Strongly Agree'.
A lack of interoperability between systems, insufficient resources, unsatisfactory education and training, and the need for greater public awareness surrounding the benefits, risks, and applications of ionising radiation were identified as principal translational challenges. These findings will help to inform a tailored innovation transfer framework for medical radiation research.
将电离辐射的医学应用和相关的辐射防护研究转化为临床实践时，往往会遇到漫长的延迟和实施不一致的情况。需要协调努力，分析欧洲基于辐射的高质量医疗保健领域创新转化的研究需求，为制定针对大规模实施辐射研究的公平创新转化框架提供信息。
在 2021 年 3 月至 9 月期间，采用德尔菲法从一系列专业利益相关者中就关键转化挑战达成共识。使用一系列包含开放式和封闭式问题的电子调查进行了总共三轮德尔菲调查。这些调查通过 EURAMED Rocc-n-Roll 联盟网络和该领域的主要医学协会进行分发。大约有 350 名专业人员受邀参与。使用 6 点李克特量表记录参与者对每个生成语句的同意程度。共识定义为中位数≥4，且≥60%的回复处于量表的上三分位。此外，还评估了回复在各轮之间的稳定性。
在第一轮德尔菲调查中，一个由 20 名成员组成的多学科小组生成了 127 个独特的语句。第二轮和第三轮德尔菲调查招募了更多的 130 名个人来评估他们对每个语句作为关键转化挑战的同意程度。通过迭代德尔菲过程共产生了 60 个共识语句，其中 55 个具有良好的稳定性。有 10 个语句被确定为高优先级挑战，其中≥80%的语句评价为“同意”或“强烈同意”。
系统之间缺乏互操作性、资源不足、教育和培训不尽人意以及公众对电离辐射的益处、风险和应用的认识不足，这些都被认为是主要的转化挑战。这些发现将有助于为医学辐射研究制定有针对性的创新转化框架。
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