St. Erik Eye Hospital, Box 4078, Solna, 171 04 Stockholm, Sweden; Department of Clinical Neuroscience, Division of Eye and Vision, St. Erik Eye Hospital, Karolinska Institutet, Tomtebodavägen 18A, plan 5, 171 77 Stockholm, Sweden.
Department of Clinical Neuroscience, Division of Eye and Vision, St. Erik Eye Hospital, Karolinska Institutet, Tomtebodavägen 18A, plan 5, 171 77 Stockholm, Sweden; Department of Pathology, Västmanland Hospital Västerås, Västerås, Sweden.
Crit Rev Oncol Hematol. 2022 Apr;172:103652. doi: 10.1016/j.critrevonc.2022.103652. Epub 2022 Mar 15.
To examine patient survival in untreated primary uveal melanoma.
Systematic review and meta-analysis.
Seven studies with a total of 19 patients were included. Fifteen patients died from metastases during a median follow-up of > 20 years. When excluding two patients with iris melanoma, fifteen of 17 patients with choroidal or ciliary body melanoma developed metastases. The cumulative disease-specific survival for these 17 patients was 71% at five years, 29% at 10 years, 18% at 15 years and 11% at 30 years. This was significantly worse than the survival in comparison cohorts of both medium-sized and large treated tumors (p < 0.001).
Among the exceedingly rare published patients with untreated primary uveal melanoma, 80-90% have developed metastases and their disease-specific survival seems to be shorter than treated patients. This could indicate that some metastases might be prevented by primary tumor treatment.
研究未经治疗的原发性葡萄膜黑色素瘤患者的生存情况。
系统评价和荟萃分析。
纳入了 7 项研究，共 19 名患者。15 名患者在中位随访时间>20 年后死于转移。排除 2 名虹膜黑色素瘤患者后，17 名脉络膜或睫状体黑色素瘤患者中有 15 名发生转移。这 17 名患者的疾病特异性生存率为：5 年时 71%，10 年时 29%，15 年时 18%，30 年时 11%。与中大和大治疗肿瘤的比较队列相比，这明显更差（p<0.001）。
在极少数已发表的未经治疗的原发性葡萄膜黑色素瘤患者中，80-90%已发生转移，其疾病特异性生存率似乎短于治疗患者。这可能表明某些转移可以通过治疗原发肿瘤来预防。
