Centre for Health Research and Development, Society for Applied Studies, New Delhi, India.
Department of Sexual and Reproductive Health and Research, UNDP/UNFPA/UNICEF/WHO/World Bank Special Programme of Research, Development and Research Training in Human Reproduction (HRP), World Health Organization, Geneve, Switzerland.
BMJ Open. 2022 Mar 18;12(3):e059583. doi: 10.1136/bmjopen-2021-059583.
The Global Health Sector Strategy on sexually transmitted infections (STIs), endorsed by the World Health Assembly in 2016 aims to end STIs as public health threat by 2030. WHO conducts global estimates of prevalence to monitor progress towards achieving the same. However, limited laboratory confirmed data exist of STIs and reproductive tract infections (RTIs) apart from few prevalence surveys among key populations and clinic-based reports, including in India. Syndromic approach is the cornerstone of RTI/STI management and to maximise the diagnostic accuracy, there is a need to determine the main aetiologies of vaginal discharge. This study aims to estimate the prevalence of common STIs and RTIs and their aetiological organisms in symptomatic and asymptomatic women living in the urban and peri-urban, mid to low socioeconomic neighbourhoods of Delhi, North India.
A cross-sectional study will be conducted among 440 married women who participated in the 'Women and Infants Integrated Interventions for Growth Study (WINGS)'. Information on sociodemographic profile, sexual and reproductive health will be collected, followed by examination and collection of vaginal swabs for nucleic acid amplification tests to diagnose , and and microscopy to identify bacterial vaginosis and . Treatment will be as per the syndromic approach recommendations in the Indian National Guidelines. Data will be analysed to estimate prevalence, presence of symptoms and signs associated with laboratory confirmed RTIs/STIs using STATA V.16.0 (StataCorp).
This study protocol has been approved by the ethics review committees of the WHO and Society for Applied Studies (SAS/ERC/RHR-RTI/STI/2020). Approval has been obtained by the WINGS investigators from SAS ethics research committee to share the contact details of the participants with the investigators. The findings will be published in peer-reviewed journals and disseminated through scientific conferences.
CTRI/2020/03/023954.
2016 年世界卫生大会通过的全球性传播感染（STI）卫生部门战略旨在到 2030 年消除 STI 对公共卫生的威胁。世卫组织进行全球流行率估计，以监测实现这一目标的进展情况。然而，除了少数重点人群的流行率调查和诊所报告外，包括印度在内的 STI 和生殖道感染（RTI）的实验室确诊数据有限。症状性方法是 RTI/STI 管理的基石，为了最大限度地提高诊断准确性，需要确定阴道分泌物的主要病因。本研究旨在估计印度北部德里市城乡和城郊中低收入社区中症状性和无症状性妇女中常见 STI 和 RTI 及其病原体的流行率。
将对参加“妇女和婴儿综合干预促进生长研究（WINGS）”的 440 名已婚妇女进行横断面研究。将收集社会人口学特征、性健康和生殖健康信息，然后进行检查并采集阴道拭子进行核酸扩增试验以诊断、和 ，并进行显微镜检查以确定细菌性阴道病和 。将根据印度国家指南中的症状性方法建议进行治疗。将使用 STATA V.16.0（StataCorp）分析数据，以估计使用实验室确诊的 RTI/STI 相关症状和体征的流行率、存在情况。
本研究方案已获得世卫组织和社会应用研究协会（SAS/ERC/RHR-RTI/STI/2020）伦理审查委员会的批准。WINGS 调查人员已获得 SAS 伦理研究委员会的批准，可以与调查人员分享参与者的联系信息。研究结果将发表在同行评议的期刊上，并通过科学会议传播。
CTRI/2020/03/023954。
