MD Internal Medicine Postgraduate Program (2023), University of British Columbia, Vancouver, Canada.
Endocrinology and Metabolism, Centre for Menstrual Cycle and Ovulation Research (CeMCOR), University of British Columbia, 2775 Laurel Street, 4th Floor, Vancouver, BC, V5Z 1M9, Canada.
Sci Rep. 2022 Mar 18;12(1):4738. doi: 10.1038/s41598-022-08658-3.
This is a prospective, observational community cohort study with the objective of investigating menstrual cramp occurrence related to ovulatory characteristics. Women reported cramp intensity on daily Menstrual Cycle Diary© records over one year. Ovulation and luteal phase lengths were assessed by validated Quantitative Basal Temperature© (QBT) analysis. Healthy, normal-weight, non-smoking community dwelling premenopausal women ages 21-41 years with two consecutive, normally ovulatory, normal-length menstrual cycles were enrolled. All 53 women, with 13.6 ± 2.8 cycles per woman, reported at least one cramp episode of median intensity 1.5 [0-4 scale; range 1.0-3.5], and 2.2 days' [range 1.0-10.2] duration. Within the 49 women who experienced all ovulatory cycle types (normal, short luteal length [SLL < 10 days] and anovulatory), median cramp intensity was greater in normal-length cycles having subclinical ovulatory disturbances (SLL and anovulatory; median 1.4 [range 0.0-2.8]) than in normally ovulatory cycles (median 1.2 [range 0.0-2.3]) (P = 0.023). Cramp Scores did not differ by ovulatory status within the 19 women having both normally ovulatory and anovulatory cycles (P = 0.222). Within-woman 1-year Cramp Scores were not different in anovulatory and normally ovulatory menstrual cycles but were more intense with ovulatory disturbances.
这是一项前瞻性、观察性的社区队列研究，旨在研究与排卵特征相关的痛经发生情况。女性在一年的时间里通过《月经周期日记》©记录报告痛经强度。通过经过验证的定量基础体温©（QBT）分析评估排卵和黄体期长度。招募了年龄在 21-41 岁、健康、体重正常、不吸烟的社区居住的绝经前女性，她们有两个连续的、正常排卵、正常长度的月经周期。所有 53 名女性（每名女性平均 13.6±2.8 个周期）报告至少有一次痛经发作，中位数强度为 1.5 [0-4 级；范围 1.0-3.5]，持续 2.2 天[范围 1.0-10.2]。在经历所有排卵周期类型（正常、黄体期短[LSL<10 天]和无排卵）的 49 名女性中，具有亚临床排卵障碍（LSL 和无排卵）的正常长度周期的痛经中位数强度大于正常排卵周期（中位数 1.4 [范围 0.0-2.8]）（P=0.023）。在 19 名同时有正常排卵和无排卵周期的女性中，排卵状态对痛经评分没有影响（P=0.222）。在无排卵和正常排卵的月经周期中，女性 1 年内的痛经评分没有差异，但排卵障碍时痛经更严重。
