Schreibman M P, Margolis-Nunno H, Halpern-Sebold L R, Goos H J, Perlman P W
Cell Tissue Res. 1986;245(3):519-24. doi: 10.1007/BF00218552.
This report demonstrates that the administration of testosterone (T) or 11-ketotestosterone (11-KT) to sexually immature (8 wks old) male platyfish (Xiphophorus maculatus) of early- and late-maturing genotypes affects the synthesis and/or release of luteinizing hormone-releasing hormone (LHRH), as assessed by immunocytochemical evaluation, increases the number and activity of pituitary gonadotropes, stimulates the production of sperm and, thus, advances the age of sexual maturation over that dictated by the genome. We also show that 11-KT and T affect different LHRH-containing centers in the brain and have differential effects on rate and degree of sexual maturation, regardless of whether the hormones are administered to early or late-maturing genotypes.
本报告表明，对性未成熟（8周龄）的早熟和晚熟基因型雄性剑尾鱼（Xiphophorus maculatus）施用睾酮（T）或11-酮睾酮（11-KT），通过免疫细胞化学评估发现，这会影响促黄体生成激素释放激素（LHRH）的合成和/或释放，增加垂体促性腺细胞的数量和活性，刺激精子产生，从而使性成熟年龄比基因组决定的年龄提前。我们还表明，无论激素施用于早熟还是晚熟基因型，11-KT和T对大脑中不同的含LHRH中心有影响，并且对性成熟的速率和程度有不同影响。
