Tian Zhiqiang, Zha Meng, Cai Limei, Michaud J P, Cheng Jie, Shen Zhongjian, Liu Xiaoming, Liu Xiaoxia
Department of Entomology, MOA Key Laboratory of Pest Monitoring and Green Management, College of Plant Protection, China Agricultural University, Beijing 100193, China.
Department of Entomology, Agricultural Research Center-Hays, Kansas State University, Hays, KS 67601, USA.
Ecotoxicol Environ Saf. 2022 Apr 1;234:113414. doi: 10.1016/j.ecoenv.2022.113414. Epub 2022 Mar 16.
Helicoverpa armigera single nucleopolyhedrovirus (HearNPV) has a long coevolutionary history with its host, exerting profound effects on larval development, physiology and immune responses, although the mechanisms mediating these effects remain unclear. We demonstrate that HearNPV infection constrains the growth and development of larvae by inducing high levels of reactive oxygen species (ROS), which increase the expression of forkhead box O transcription factor (FoxO). FoxO upregulates the expression of peroxiredoxin 1 (Prx1) which serves to regulate larval development and immune responses following HearNPV infection. Collectively, our results provide novel insights into the role of Prx1 in larval development and immunity subsequent to HearNPV infection. Further investigation of the oxidative stress induced by HearNPV in H. armigera and its interactions with host immunity could yield novel insights useful in agricultural pest control.
棉铃虫单核衣壳核型多角体病毒（HearNPV）与其宿主有着漫长的共同进化历史，对幼虫的发育、生理和免疫反应产生深远影响，尽管介导这些影响的机制尚不清楚。我们证明，HearNPV感染通过诱导高水平的活性氧（ROS）来抑制幼虫的生长和发育，ROS会增加叉头框O转录因子（FoxO）的表达。FoxO上调过氧化物还原酶1（Prx1）的表达, Prx1在HearNPV感染后调节幼虫发育和免疫反应。总的来说，我们的结果为Prx1在HearNPV感染后幼虫发育和免疫中的作用提供了新的见解。进一步研究HearNPV诱导棉铃虫产生的氧化应激及其与宿主免疫的相互作用，可能会为农业害虫防治提供新的有用见解。
