糖尿病犬的促凝和抗凝血浆指标显示犬糖尿病中抗凝血酶 III 水平升高。
Procoagulant and anticoagulant plasma indicators in diabetic dogs showing increased antithrombin III levels in canine diabetes mellitus.
机构信息
Department and Clinic of Animal Internal Diseases, Sub-Department of Internal Diseases of Small Animals, University of Life Sciences in Lublin, Lublin, Poland.
Department of Epizootiology and Clinic of Infectious Diseases, University of Life Sciences in Lublin, Lublin, Poland.
出版信息
BMC Vet Res. 2022 Mar 19;18(1):108. doi: 10.1186/s12917-022-03179-7.
BACKGROUND
Diabetes mellitus (DM) often leads to dangerous thromboembolic complications in humans. DM is also a relatively common endocrinopathy of dogs. There is scarce information regarding procoagulant and anticoagulant plasma indicators in this disease. The aim of the study was to evaluate the levels of the selected plasma haemostatic parameters in dogs suffering from diabetes. The study group consisted of 20 dogs meeting all the inclusion criteria, with fasting glycaemia exceeding 11.1 mmol/l. The control group consisted of 15 healthy dogs presented for routine examination. An evaluation of the prothrombin time (PT); and fibrinogen, D-dimer and antithrombin III (ATIII) levels was performed.
RESULTS
Except for ATIII activity, the haemostatic parameter differences were not statistically significant. High values of ATIII activity were observed in 90% of diabetic dogs. On average, the values amounted to 166.6% and were 31.4% higher than those in the control group. The ATIII activity in the diabetic group was significantly higher than that in the control group (p = 0.0004).
CONCLUSIONS
Here, we report elevated levels of ATIII in diabetic dogs. This finding may suggest the protective role of ATIII against potential thrombotic events. However, the exact role of ATIII in dog diabetes remains unclear.
背景
糖尿病（DM）常导致人类发生危险的血栓栓塞并发症。DM 也是犬类较为常见的内分泌疾病。关于这种疾病的促凝和抗凝血浆指标的信息很少。本研究的目的是评估患有糖尿病的犬只的选定血浆止血参数水平。研究组由 20 只符合所有纳入标准的犬只组成，其空腹血糖超过 11.1mmol/L。对照组由 15 只接受常规检查的健康犬组成。评估了凝血酶原时间（PT）；纤维蛋白原、D-二聚体和抗凝血酶 III（ATIII）水平。
结果
除了 ATIII 活性外，止血参数差异无统计学意义。90%的糖尿病犬的 ATIII 活性较高。平均而言，这些值达到了 166.6%，比对照组高 31.4%。糖尿病组的 ATIII 活性明显高于对照组（p=0.0004）。
结论
在这里，我们报告了糖尿病犬 ATIII 水平升高。这一发现可能表明 ATIII 对潜在的血栓事件具有保护作用。然而，ATIII 在犬糖尿病中的确切作用尚不清楚。
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