多囊卵巢综合征和甲状腺功能减退对乳腺纤维囊性改变风险的影响：一项荟萃分析。
The effect of the polycystic ovary syndrome and hypothyroidism on the risk of fibrocystic breast changes: a meta-analysis.
作者信息
Kohnepoushi Parisa, Dehghanbanadaki Hojat, Mohammadzedeh Pardis, Nikouei Maziar, Moradi Yousef
机构信息
Student Research Committee, Kurdistan University of Medical Sciences, Sanandaj, Iran.
Students Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran.
出版信息
Cancer Cell Int. 2022 Mar 19;22(1):125. doi: 10.1186/s12935-022-02547-5.
This meta-analysis aimed to determine the pooled association between polycystic ovary syndrome (PCOS), hypothyroidism, and fibrocystic breast changes. We searched important databases, including PubMed (Medline), Scopus, Web of Science, and Embase to retrieve all relevant studies published from 1990 to April 2021. The bias risk of selected articles was assessed based on the JBI checklist. Our search strategy yielded a total of 487 articles from the international databases. After screening their full-texts, 6 articles met the inclusion criteria and were considered for meta-analysis. The effect of PCOS on the incidence of fibrocystic breast changes was 2.49 (95% CI 1.85-3.34). Also, the effect of hypothyroidism on the incidence of fibrocystic breast changes was 1.90 (95% CI 0.92-3.93). The results showed that women with PCOS were at higher risks to develop fibrocystic breast changes.
本荟萃分析旨在确定多囊卵巢综合征（PCOS）、甲状腺功能减退症与乳腺纤维囊性改变之间的合并关联。我们检索了重要数据库，包括PubMed（医学索引数据库）、Scopus、科学网和Embase，以获取1990年至2021年4月发表的所有相关研究。根据JBI检查表评估所选文章的偏倚风险。我们的检索策略从国际数据库中共获得487篇文章。在筛选其全文后，6篇文章符合纳入标准并被纳入荟萃分析。PCOS对乳腺纤维囊性改变发生率的影响为2.49（95%CI 1.85 - 3.34）。此外，甲状腺功能减退症对乳腺纤维囊性改变发生率的影响为1.90（95%CI 0.92 - 3.93）。结果表明，患有PCOS的女性发生乳腺纤维囊性改变的风险更高。
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