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关于岩藻聚糖硫酸酯作为抗病毒剂对抗病毒感染的最新综述。

A state-of-the-art review on fucoidan as an antiviral agent to combat viral infections.

机构信息

Algal Biotechnology and Molecular Systematic Laboratory, Post Graduate Department of Botany, Berhampur University, Bhanja Bihar, Berhampur 760007, Odisha, India; Department of Biotechnology, Sangmyung University, Seoul 03016, Republic of Korea.

Algal Biotechnology and Molecular Systematic Laboratory, Post Graduate Department of Botany, Berhampur University, Bhanja Bihar, Berhampur 760007, Odisha, India.

出版信息

Carbohydr Polym. 2022 Sep 1;291:119551. doi: 10.1016/j.carbpol.2022.119551. Epub 2022 May 2.

Abstract

As a significant public health hazard with several drug side effects during medical treatment, searching for novel therapeutic natural medicines is promising. Sulfated polysaccharides from algae, such as fucoidan, have been discovered to have a variety of medical applications, including antibacterial and immunomodulatory properties. The review emphasized on the utilization of fucoidan as an antiviral agent against viral infections by inhibiting their attachment and replication. Moreover, it can also trigger immune response against viral infection in humans. This review suggested to be use the fucoidan for the potential protective remedy against COVID-19 and addressing the antiviral activities of sulfated polysaccharide, fucoidan derived from marine algae that could be used as an anti-COVID19 drug in near future.

摘要

作为一种严重的公共卫生危害,在医疗过程中存在多种药物副作用,因此寻找新型治疗天然药物具有广阔的前景。藻类中的硫酸多糖,如褐藻糖胶,已被发现具有多种医疗应用,包括抗菌和免疫调节特性。本综述强调了褐藻糖胶作为一种抗病毒药物的利用,通过抑制病毒的附着和复制来对抗病毒感染。此外,它还可以引发人体对病毒感染的免疫反应。本综述建议使用褐藻糖胶作为预防 COVID-19 的潜在保护疗法,并探讨了源自海洋藻类的硫酸多糖褐藻糖胶的抗病毒活性,它可能在不久的将来被用作抗 COVID-19 的药物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25cf/9057937/93c44c576c90/ga1_lrg.jpg

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