OncoWitan, Scientific Consulting Office, Lille (Wasquehal), 59290, France.
J Oral Biosci. 2022 Jun;64(2):183-192. doi: 10.1016/j.job.2022.03.002. Epub 2022 Mar 17.
Novel affordable medications are needed to treat chronic periodontitis, which is one of the most common dental pathologies worldwide. Extracts prepared from the rhizome of the medicinal plant Boesenbergia rotunda (L.) Mansf., commonly known as fingerroot, are used to treat a variety of human pathologies. These extracts contain potent anti-inflammatory compounds, including the chalcone derivative panduratin A (Pa-A), which is the lead compound of a series of analogues, designated panduratins A to Y. The anti-inflammatory properties of the extracts of B. rotunda and the most abundant bioactive products found in these extracts (including Pa-A, 4-hydroxyoanduratin, isopanduratin, and others) have been reviewed. A standardized extract of the plant has promising utility in the treatment of gingival inflammation. The effects are characterized by three actions: (i) a direct antimicrobial effect against fungi and oral pathogens such as Porphyromonas gingivalis, (ii) a marked anti-inflammatory effect via a reduced production of mediators, like prostaglandin E2 and different interleukins, and (iii) a dual bone-preserving effect, with a reduction in bone resorption and an increase in bone formation. Acting as a protease inhibitor, Pa-A is one of the main active ingredients of the extract, implicated in these actions. A Pa-A-standardized extract of B. rotunda has been used in humans for treating dyspepsia. The product is safe and well-tolerated. The development of panduratin-containing dental products, for the prevention and treatment of periodontitis, has been proposed. The structural analogues, Pa-A to-Y, should also be investigated for the treatment of dental inflammation.
需要新型的经济实惠的药物来治疗慢性牙周炎，这是全球最常见的牙科疾病之一。药用植物 Boesenbergia rotunda（L.）Mansf. 的根茎提取物，通常称为手指根，用于治疗多种人类疾病。这些提取物含有有效的抗炎化合物，包括查尔酮衍生物 panduratin A（Pa-A），它是一系列类似物的先导化合物，被指定为 panduratins A 至 Y。Boesenbergia rotunda 提取物的抗炎特性和这些提取物中发现的最丰富的生物活性产物（包括 Pa-A、4-羟基奥达他林、异潘达林和其他）已被综述。该植物的标准化提取物在治疗牙龈炎症方面具有广阔的应用前景。其作用特点有三：（i）对真菌和口腔病原体（如牙龈卟啉单胞菌）具有直接的抗菌作用，（ii）通过减少前列腺素 E2 和不同白细胞介素等介质的产生发挥显著的抗炎作用，（iii）具有双重骨保护作用，减少骨质吸收和增加骨质形成。作为一种蛋白酶抑制剂，Pa-A 是提取物中的主要活性成分之一，参与了这些作用。Boesenbergia rotunda 的 Pa-A 标准化提取物已在人类中用于治疗消化不良。该产品安全且耐受良好。已经提出了开发含 panduratin 的口腔产品用于预防和治疗牙周炎。还应研究结构类似物 Pa-A 至 Y 用于治疗牙科炎症。
