JH-Institute of Molecular Medicine, Jamia Hamdard, New Delhi, India.
Carter Immunology Center, University of Virginia, Charlottesville, VA, USA.
Eur J Immunol. 2022 May;52(5):696-704. doi: 10.1002/eji.202149624. Epub 2022 Apr 4.
The macrophages contribute to host defense against intracellular pathogens such as mycobacteria. Mycobacteria interact with macrophages altering their polarization state, which propagates establishment of infection. Thus, molecular macrophage properties in mycobacterial infections are critical both for understanding the biology of the infections as well as identifying therapeutic targets. Here, we review recent advances in the understanding how altered macrophage polarization in mycobacterial infections may lead to the design of targeted therapies that may reprogram these macrophages for enhanced mycobactericidal function.
巨噬细胞有助于宿主抵御分枝杆菌等细胞内病原体。分枝杆菌与巨噬细胞相互作用，改变其极化状态，从而促进感染的建立。因此，分枝杆菌感染中巨噬细胞的分子特性对于理解感染的生物学以及确定治疗靶点都至关重要。在这里，我们综述了关于分枝杆菌感染中巨噬细胞极化改变如何导致设计靶向治疗的最新进展，这些治疗可能会重新编程这些巨噬细胞，增强其杀菌功能。
