Ho Chi Minh City Hospital of Dermato-Venereology, Ho Chi Minh City, Vietnam.
Dermatol Ther. 2022 Jun;35(6):e15464. doi: 10.1111/dth.15464. Epub 2022 Mar 27.
Generalized erythrodermic psoriasis (GEP) is a rare and potentially life-threatening variant of psoriasis. Possible triggers that have been identified to date include poorly controlled psoriasis, medications, abrupt discontinuation of anti-psoriatic treatment, and underlying systemic illnesses. However, vaccines have rarely been reported to exacerbate GEP. Herein, we report two unique cases with GEP exacerbated following a dose of the BNT162b2 mRNA vaccine for COVID-19 (as their second dose, the first being the mRNA-1273 vaccine). Based on our observations and a literature review, vaccination was considered the most likely trigger of GEP due to the close temporal relationship between the second vaccination and the onset of GEP.
泛发性红皮病型银屑病（GEP）是一种罕见且可能危及生命的银屑病变体。迄今为止已确定的可能诱因包括控制不佳的银屑病、药物、抗银屑病治疗的突然中断以及潜在的系统性疾病。然而，疫苗很少有报道会加重 GEP。在此，我们报告了两例在接种第二剂 BNT162b2 mRNA 疫苗（第一剂为 mRNA-1273 疫苗）后因 COVID-19 而出现 GEP 加重的独特病例。基于我们的观察和文献复习，由于第二次接种与 GEP 发病之间的密切时间关系，我们认为疫苗接种是 GEP 最可能的诱因。
