Amaral L, Schwarz U, Lorian V
Drugs Exp Clin Res. 1986;12(8):653-6.
Nalidixic acid, novobiocin, oxolinic acid and nitrofurantoin, each at low concentrations, cause filamentation of Gram-negative bacilli. Filamentation induced by beta-lactam antibiotics has been correlated to the binding of these antibiotics to specific penicillin-binding proteins (PBPs) of the envelope of Gram-negative bacilli. The studies reported herein indicate that the former group of non-beta-lactam antibiotics do not bind to any of the PBPs of Escherichia coli. However, PBP 1a, PBP 4 and PBP 5/6 of the filaments induced by these agents are increased significantly.
萘啶酸、新生霉素、恶喹酸和呋喃妥因在低浓度时均可导致革兰氏阴性杆菌形成丝状体。β-内酰胺类抗生素诱导的丝状体形成与这些抗生素与革兰氏阴性杆菌包膜上特定青霉素结合蛋白（PBPs）的结合有关。本文报道的研究表明，前一组非β-内酰胺类抗生素不与大肠杆菌的任何一种PBPs结合。然而，由这些药物诱导形成的丝状体中的PBP 1a、PBP 4和PBP 5/6显著增加。
