三种典型城市污水处理厂中四环素的转化产物。
Transformation products of tetracyclines in three typical municipal wastewater treatment plants.
机构信息
SCNU Environmental Research Institute, Guangdong Provincial Key Laboratory of Chemical Pollution and Environmental Safety & MOE Key Laboratory of Theoretical Chemistry of Environment, South China Normal University, Guangzhou 510006, China; School of Environment, South China Normal University, Guangzhou 510006, China; School of Chemical Engineering and Energy Technology, Dongguan University of Technology, Dongguan 523808, China.
SCNU Environmental Research Institute, Guangdong Provincial Key Laboratory of Chemical Pollution and Environmental Safety & MOE Key Laboratory of Theoretical Chemistry of Environment, South China Normal University, Guangzhou 510006, China; School of Environment, South China Normal University, Guangzhou 510006, China.
出版信息
Sci Total Environ. 2022 Jul 15;830:154647. doi: 10.1016/j.scitotenv.2022.154647. Epub 2022 Mar 18.
Antibiotics in the environment could undergo various processes with formation of transformation products, but little has been known about their occurrence and (eco)toxicological consequences. Here we investigated the occurrence and fate of nine transformation products of four tetracyclines (tetracycline, oxytetracycline, chlortetracycline and doxycycline) in three municipal wastewater treatment plants (WWTPs) in Guangzhou, China. The results showed the detection of all the tetracyclines and their transformation products in the WWTPs, with mean concentrations ranging from 17.8 ng/L (anhydrotetracycline) to 49.1 ng/L (oxytetracycline) in influent, 3.03 ng/L (tetracycline) to 6.94 ng/L (4-epi-chlortetracycline) in effluent, and 19.8 ng/g (isochlortetracycline) to 503 ng/g (4-epi-tertracycline) in sludge, respectively. The transformation products of tetracycline, oxytetracycline, chlortetracycline and doxycycline accounted for 73%-83%, 26%-52%, 70%-73% and 69%-74% of total concentrations, respectively. The aqueous removal rates of tetracyclines and their transformation products in the three WWTPs ranged from 18.4% (demethyl-chlortetracycline) to 93.7% (oxytetracycline). Mass balance analysis based on both aqueous and solid phase showed that their removals were mainly attributed to the sludge adsorption. Residual tetracyclines and their transformation products in the effluents would pose no obvious ecological risks to three aquatic organisms (green algae, daphnia and fish). However, 43.5% of sludge samples had high risks from these tetracyclines and transformation products, especially the compounds with poor biodegradability. The results from this study suggest that transformation products should be included in future environmental monitoring and control.
抗生素在环境中可能会经历各种转化过程，形成转化产物，但人们对它们的发生和（生态）毒理学后果知之甚少。在这里，我们研究了四种四环素（四环素、土霉素、金霉素和强力霉素）的九种转化产物在广州三个城市污水处理厂（WWTP）中的发生和归宿。结果表明，所有四环素及其转化产物均在 WWTP 中检出，进水浓度范围为 17.8ng/L（脱水四环素）至 49.1ng/L（土霉素），出水浓度范围为 3.03ng/L（四环素）至 6.94ng/L（4-表金霉素），污泥浓度范围为 19.8ng/g（差向金霉素）至 503ng/g（4-表四环素）。四环素、土霉素、金霉素和强力霉素的转化产物分别占总浓度的 73%-83%、26%-52%、70%-73%和 69%-74%。三种 WWTP 中四环素及其转化产物的水相去除率为 18.4%（去甲金霉素）至 93.7%（土霉素）。基于水相和固相的质量平衡分析表明，它们的去除主要归因于污泥吸附。残留的四环素及其转化产物在废水中对三种水生生物（绿藻、水蚤和鱼类）不会造成明显的生态风险。然而，43.5%的污泥样品中这些四环素和转化产物的风险很高，尤其是那些生物降解性差的化合物。本研究结果表明，未来的环境监测和控制应包括转化产物。
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