Department of Oncology, The Second Affiliated Hospital of Anhui Medical University, Hefei, 230601, Anhui, China; Department of Oncology, Anhui Medical University, Hefei, 230032, Anhui, China.
Department of Hematology, The Third People's Hospital of Zhengzhou, Zhengzhou, 450000, Henan, China.
Cancer Lett. 2022 Jun 28;536:215648. doi: 10.1016/j.canlet.2022.215648. Epub 2022 Mar 17.
Depression is a common and recurrent mental illness with a complicated etiology, but the specific pathogenesis is not clear. Breast cancer increases susceptibility to depression, which leads to a poor prognosis. Rapid advances in the understanding of tumor immunology and neuroimmunology have provided new evidence for the pathogenesis of depression. Dysfunction of immune cells and cytokines cause depression by affecting tryptophan metabolism, serotonin levels, and blood-brain barrier permeability. Dysregulation of cytokines or intestinal flora may be shared between patients with depression and breast cancer. This review presents an overview of immune dysregulation in breast cancer patients with depression and proposes future alternative research directions and interventions.
抑郁症是一种常见且反复发作的精神疾病，病因复杂，但具体发病机制尚不清楚。乳腺癌增加了患抑郁症的易感性，导致预后不良。肿瘤免疫学和神经免疫学的快速发展为抑郁症的发病机制提供了新的证据。免疫细胞和细胞因子功能障碍通过影响色氨酸代谢、血清素水平和血脑屏障通透性导致抑郁症。细胞因子或肠道菌群失调可能在抑郁症和乳腺癌患者中共同存在。本文综述了伴有抑郁症的乳腺癌患者的免疫失调，并提出了未来的替代研究方向和干预措施。
