Siesjö B K
Eur Neurol. 1986;25 Suppl 1:45-56. doi: 10.1159/000116060.
An account is given of calcium metabolism in the brain, with particular reference to the possibility that loss of calcium homeostasis is the cause of ischemic neuronal necrosis. The hypothesis of calcium-related cell damage is based on the fact that dense ischemia leads to an influx of calcium into cells, and that raised intracellular calcium concentrations activate lipases and proteases, and cause disaggregation of neurotubuli and enhanced protein phosphorylation. Such changes have the potential of inducing membrane damage and dysfunction of intracellular transport mechanisms. An attempt is made to critically review available evidence on the calcium hypothesis of cell death.
本文阐述了大脑中的钙代谢，特别提及钙稳态丧失可能是缺血性神经元坏死原因的可能性。钙相关细胞损伤的假说基于以下事实：严重缺血会导致钙流入细胞，细胞内钙浓度升高会激活脂肪酶和蛋白酶，导致神经微管解聚并增强蛋白质磷酸化。这些变化有可能导致膜损伤和细胞内运输机制功能障碍。本文试图对关于细胞死亡钙假说的现有证据进行批判性综述。
