Hoepffner W, Hubl W
Exp Clin Endocrinol. 1986 Jul;87(2):189-94. doi: 10.1055/s-0029-1210542.
The diurnal rhythm of 17-hydroxyprogesterone concentration in the saliva was determined in 11 patients with congenital adrenal hyperplasia ranging in age from 9 to 20 years. A total of 21 tests were performed using a 17-OHP-enzyme immunoassay. The investigations were carried out during normal school or working days. The tests were done 16 times in patients with optimal therapeutic control and 5 times in patients with undertreatment. The concentrations of saliva 17-OHP in the morning were significantly lower after a therapy interval during the night of 8 hours than of more than 10 hours. In patients with poor substitution all values of the days were higher than in patients with optimal therapy control. The morning values are appropriate for the evaluation of the therapy control. With regular 8 hours' therapy intervals the limit between normal and pathological values may be about 500 pmol/l saliva.
对11例年龄在9至20岁之间的先天性肾上腺皮质增生症患者的唾液中17 - 羟孕酮浓度的昼夜节律进行了测定。使用17 - OHP酶免疫测定法共进行了21次检测。研究在正常上学日或工作日进行。在治疗控制最佳的患者中进行了16次检测，在治疗不足的患者中进行了5次检测。夜间治疗间隔为8小时后早晨唾液中17 - OHP的浓度显著低于治疗间隔超过10小时后的浓度。替代治疗不佳的患者全天所有值均高于治疗控制最佳的患者。早晨的值适用于评估治疗控制情况。在治疗间隔为常规8小时的情况下，正常与病理值之间的界限可能约为唾液500 pmol/l。
