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中药方剂四物汤通过改善肠道菌群和巨噬细胞极化抑制食管前病变。

Chinese Medicine Formula Siwu-Yin Inhibits Esophageal Precancerous Lesions by Improving Intestinal Flora and Macrophage Polarization.

作者信息

Shi Hui-Juan, Chen Xuan-Yu, Chen Xin-Ran, Wu Zhong-Bing, Li Jian-Yong, Sun Ya-Qin, Shi Dong-Xuan, Li Jing

机构信息

Department of Traditional Chinese Medicine, The Fourth Hospital of Hebei Medical University, Hebei Cancer Hospital, Shijiazhuang, China.

Institute for Biotechnology, St. John's University, Queens, NY, United States.

出版信息

Front Pharmacol. 2022 Mar 3;13:812386. doi: 10.3389/fphar.2022.812386. eCollection 2022.

DOI:10.3389/fphar.2022.812386
PMID:35308250
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8927885/
Abstract

Siwu-Yin (SWY), a traditional Chinese medicinal formula, can replenish blood and nourish Yin. It was recorded in ancient Chinese medicine books in treating esophageal dysphagia, which has similar symptoms and prognosis with esophageal precancerous lesions and esophageal cancer. However, its effect has not been established . This study explores the antiesophageal cancer effect of SWY on rats with esophageal precancerous lesions. By performing 16S rRNA gene sequencing and metabolomics, it was suggested that SWY may improve the composition of intestinal flora of rats by regulating the synthesis and secretion of bile acids. In addition, flow cytometry results showed that SWY treatment modified tumor microenvironment by improving macrophage polarization and therefore inhibiting the occurrence of esophageal precancerous lesions.

摘要

四物汤（SWY）是一种中药配方，具有补血滋阴的功效。它在中国古代医书中有治疗食管吞咽困难的记载，食管吞咽困难与食管癌前病变和食管癌有相似的症状和预后。然而，其疗效尚未得到证实。本研究探讨四物汤对食管前病变大鼠的抗食管癌作用。通过进行16S rRNA基因测序和代谢组学分析，结果表明四物汤可能通过调节胆汁酸的合成和分泌来改善大鼠肠道菌群的组成。此外，流式细胞术结果显示，四物汤治疗可通过改善巨噬细胞极化来改变肿瘤微环境，从而抑制食管前病变的发生。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3089/8927885/6ff69d5f8ee1/fphar-13-812386-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3089/8927885/b1480145d1d9/fphar-13-812386-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3089/8927885/bf06f4c9d9a1/fphar-13-812386-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3089/8927885/766fe7e831e6/fphar-13-812386-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3089/8927885/d113c1cc64c5/fphar-13-812386-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3089/8927885/4d069cf5319c/fphar-13-812386-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3089/8927885/4c8537e2fbb5/fphar-13-812386-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3089/8927885/8c47a31c6b33/fphar-13-812386-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3089/8927885/6ff69d5f8ee1/fphar-13-812386-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3089/8927885/b1480145d1d9/fphar-13-812386-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3089/8927885/bf06f4c9d9a1/fphar-13-812386-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3089/8927885/766fe7e831e6/fphar-13-812386-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3089/8927885/d113c1cc64c5/fphar-13-812386-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3089/8927885/4d069cf5319c/fphar-13-812386-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3089/8927885/4c8537e2fbb5/fphar-13-812386-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3089/8927885/8c47a31c6b33/fphar-13-812386-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3089/8927885/6ff69d5f8ee1/fphar-13-812386-g008.jpg

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Recent Pat Anticancer Drug Discov. 2021;16(2):222-238. doi: 10.2174/1574892816666210218220943.
3
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Front Immunol. 2023 Feb 6;14:1087755. doi: 10.3389/fimmu.2023.1087755. eCollection 2023.
4
Preventive effect of (Gaertn.) Roxb. extract on mice infected with .石榴皮提取物对感染 的小鼠的预防作用。
Front Cell Infect Microbiol. 2023 Jan 9;12:1054205. doi: 10.3389/fcimb.2022.1054205. eCollection 2022.
Pharm Biol. 2020 Dec;58(1):655-663. doi: 10.1080/13880209.2020.1779318.
4
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5
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