Vural Selahattin, Aydin Ismail, Kesicioglu Tugrul
General Surgery, Giresun University Faculty of Medicine, Giresun, TUR.
Cureus. 2022 Feb 12;14(2):e22146. doi: 10.7759/cureus.22146. eCollection 2022 Feb.
Acute cholecystitis (AC) is one of the most common gastrointestinal diseases that require hospitalization and surgical treatment. The treatment of the disease depends upon the severity of the disease and the patients' medical status.
In this study, we aimed to investigate if there is an association between the serum C-reactive protein (CRP) value and treatment response and the duration and length of hospital stay in AC patients who are treated conservatively.
The medical records of all patients with the diagnosis of AC who were treated with conservative management were included in the study. The demographic and laboratory data including CRP level at first admission to hospital, length of hospital stay, and complications during the conservative treatment were obtained from the patients' records. Patients were divided into two groups according to the treatment response and length of hospital stay. Group 1 patients were defined as patients who responded to the medical treatment in less than three days, and Group 2 patients were defined as patients who did not respond to the medical treatment in three days and stayed at the hospital for more than three days.
We identified 101 patients with AC treated medically. Mean age (51.3 ± 16.3, 59.5 ± 15.7; p = 0.013), total leukocyte count (11.8 ± 4.4, 8.2 ± 2.8; p = 0.0005), and CRP value (19.3 ± 13.9, 9.6 ± 5.2; p = 0.0003) were higher in Group 2 compared to Group 1. Correlation analyses demonstrated a significant positive association between the length of hospital stay, total leukocyte count (r = 0.35; p = 0.0002), and CRP value (r = 0.59; p = 0.0004).
We found that CRP level is associated with treatment duration and hospital stay in AC patients. However, large-scale, prospective further studies are needed to confirm our results and to determine whether CRP levels can be used to discriminate which patient would benefit from medical treatment.
急性胆囊炎（AC）是最常见的需要住院和手术治疗的胃肠道疾病之一。该疾病的治疗取决于疾病的严重程度和患者的医疗状况。
在本研究中，我们旨在调查保守治疗的AC患者血清C反应蛋白（CRP）值与治疗反应、住院时间和住院时长之间是否存在关联。
本研究纳入了所有诊断为AC并接受保守治疗的患者的病历。从患者记录中获取人口统计学和实验室数据，包括首次入院时的CRP水平、住院时长以及保守治疗期间的并发症。根据治疗反应和住院时长将患者分为两组。第1组患者定义为在三天内对药物治疗有反应的患者，第2组患者定义为在三天内对药物治疗无反应且住院超过三天的患者。
我们确定了101例接受药物治疗的AC患者。第2组患者的平均年龄（51.3±16.3，59.5±15.7；p = 0.013）、白细胞总数（11.8±4.4，8.2±2.8；p = 0.0005）和CRP值（19.3±13.9，9.6±5.2；p = 0.0003）均高于第1组。相关性分析表明，住院时长与白细胞总数（r = 0.35；p = 0.0002）和CRP值（r = 0.59；p = 0.0004）之间存在显著正相关。
我们发现CRP水平与AC患者的治疗持续时间和住院时间有关。然而，需要大规模、前瞻性的进一步研究来证实我们的结果，并确定CRP水平是否可用于区分哪些患者将从药物治疗中获益。
