Predicting Motor Responsiveness to Deep Brain Stimulation with Machine Learning.

Deep brain stimulation is a complex movement disorder intervention that requires highly invasive brain surgery. Clinicians struggle to predict how patients will respond to this treatment. To address this problem, we are working toward developing a clinical tool to help neurologists predict deep brain stimulation response. We analyzed a cohort of 105 Parkinson's patients who underwent deep brain stimulation at Vanderbilt University Medical Center. We developed binary and multicategory models for predicting likelihood of motor symptom reduction after undergoing deep brain stimulation. We compared the performances of our best models to predictions made by neurologist experts in movement disorders. The strongest binary classification model achieved a 10-fold cross validation AUC of 0.90, outperforming the best neurologist predictions (0.56). These results are promising for future clinical applications, though more work is necessary to validate these findings in a larger cohort and taking into consideration broader quality of life outcome measures.