Mancabelli Leonardo, Milani Christian, Fontana Federico, Lugli Gabriele Andrea, Tarracchini Chiara, Turroni Francesca, van Sinderen Douwe, Ventura Marco
Laboratory of Probiogenomics, Department of Chemistry, Life Sciences and Environmental Sustainability, University of Parma, Parma, Italy.
Interdepartmental Research Centre "Microbiome Research Hub", University of Parma, Parma, Italy.
J Oral Microbiol. 2022 Mar 16;14(1):2051336. doi: 10.1080/20002297.2022.2051336. eCollection 2022.
The Human Respiratory Tract (HRT) is colonized by various microbial taxa, known as HRT microbiota, in a manner that is indicative of mutualistic interaction between such microorganisms and their host.
To investigate the microbial composition of the HRT and its possible correlation with the different compartments of the respiratory tract.
In the current study, we performed an in-depth meta-analysis of 849 HRT samples from public shotgun metagenomic datasets obtained through several distinct collection methods.
The statistical robustness provided by this meta-analysis allowed the identification of 13 possible HRT-specific Community State Types (CSTs), which appear to be specific to each anatomical region of the respiratory tract. Furthermore, functional characterization of the metagenomic datasets revealed specific microbial metabolic features correlating with the different compartments of the respiratory tract.
The meta-analysis here performed suggested that the variable presence of certain bacterial species seems to be linked to a location-related abundance gradient in the HRT and seems to be characterized by a specific microbial metabolic capability.
人类呼吸道（HRT）被各种微生物类群定殖，这些微生物类群被称为HRT微生物群，其定殖方式表明这些微生物与其宿主之间存在互利共生相互作用。
研究HRT的微生物组成及其与呼吸道不同部位的可能相关性。
在本研究中，我们对通过几种不同收集方法获得的公共鸟枪法宏基因组数据集的849个HRT样本进行了深入的荟萃分析。
该荟萃分析提供的统计稳健性使得能够识别出13种可能的HRT特异性群落状态类型（CST），这些类型似乎特定于呼吸道的每个解剖区域。此外，宏基因组数据集的功能表征揭示了与呼吸道不同部位相关的特定微生物代谢特征。
此处进行的荟萃分析表明，某些细菌物种存在的变化似乎与HRT中与位置相关的丰度梯度有关，并且似乎具有特定的微生物代谢能力。
