50 赫兹正弦振动对去卵巢骨质疏松大鼠子宫的影响。
Effect of 50-Hertz Sinusoidal Vibration on the Uterus in Ovariectomy-Induced Osteoporotic Rats.
机构信息
Biomedical Engineering Research Laboratory, School of Information Engineering, Guangdong Medical University, Dongguan 523808, China.
Guangdong Zhanjiang Institute of Marine Medicine, Zhanjiang 524023, China.
出版信息
Comput Math Methods Med. 2022 Mar 11;2022:9619867. doi: 10.1155/2022/9619867. eCollection 2022.
OBJECTIVE
To evaluate the influence of sinusoidal vibration (50-Hertz) stimulation on the uterus of osteoporotic rats.
METHODS
We constructed an osteoporosis rat model by ovariectomy (OVX). 36 3-month-old Sprague Dawley rats were randomly divided into the control group, vibrating group, sham operation group, sham operation vibrating group, OVX group, and OVX vibrating group ( = 6 per group). Rats started to vibrate one week after the operation: one 10 minutes 50-Hertz sinusoidal vibration per day, except for Saturday and Sunday. In the second, 8, and 12 week after vibration stimulation, rats were sacrificed in batches. And then, the uteruses were taken out to measure the wet weight and calculate uterus relative wet weight.
RESULTS
Compared with the control group, OVA induced a significant increase in wet weight and relative wet weight in rat uterus. The vibration was to the uterus wet weight and the uterus relative wet weight in ovariectomized rats and at the same time had no significant effect, but the 12-week prolonged vibration can significantly reduce the uterus wet weight and the uterus relative wet weight in ovariectomized rats than 2 weeks.
CONCLUSIONS
The uterus wet weight and the uterus relative wet weight were increased in the OVA-induced osteoporosis rats. The 50-Hertz sinusoidal vibration had no significant effect on the uterus wet weight and the uterus relative wet weight in the ovariectomized rats at the same time, but 12 weeks of vibration can significantly reduce the uterine wet weight and uterine relative wet weight of ovariectomized rats. And the uterus relative wet weight can be used as a new indicator of stimulating the uterus.
目的
评估正弦振动（50 赫兹）刺激对骨质疏松症大鼠子宫的影响。
方法
我们通过卵巢切除术（OVX）构建了骨质疏松症大鼠模型。36 只 3 月龄 Sprague Dawley 大鼠随机分为对照组、振动组、假手术组、假手术振动组、OVX 组和 OVX 振动组（每组 6 只）。大鼠在手术后一周开始振动：每天进行一次 10 分钟 50 赫兹正弦振动，周六和周日除外。在振动刺激后的第 2、8 和 12 周分批处死大鼠。然后取出子宫，测量湿重并计算子宫相对湿重。
结果
与对照组相比，OVX 导致大鼠子宫湿重和相对湿重显著增加。振动对去卵巢大鼠的子宫湿重和子宫相对湿重没有显著影响，但 12 周的延长振动可以显著降低去卵巢大鼠的子宫湿重和子宫相对湿重，而 2 周的振动则没有显著影响。
结论
OVX 诱导的骨质疏松症大鼠子宫湿重和相对湿重增加。50 赫兹正弦振动对去卵巢大鼠的子宫湿重和相对湿重没有显著影响，但 12 周的振动可以显著降低去卵巢大鼠的子宫湿重和子宫相对湿重。并且子宫相对湿重可以作为刺激子宫的新指标。
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