Liang Zixin, Li Shanshan, Wang Zhiyu, Zhou Junting, Huang Ziyue, Li Jiehan, Bao Haolin, Yam Judy Wai Ping, Xu Yi
Department of Hepatopancreatobiliary Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
School of Pharmacy, Anhui Engineering Technology Research Center of Biochemical Pharmaceutical, Bengbu Medical University, Bengbu, Anhui, China.
J Clin Transl Hepatol. 2025 Apr 28;13(4):315-326. doi: 10.14218/JCTH.2024.00401. Epub 2025 Jan 14.
Hepatocellular carcinoma (HCC) is one of the deadliest malignant tumors in the world, and its incidence and mortality have increased year by year. HCC research has increasingly focused on understanding its pathogenesis and developing treatments.The Wnt signaling pathway, a complex and evolutionarily conserved signal transduction system, has been extensively studied in the genesis and treatment of several malignant tumors. Recent investigations suggest that the pathogenesis of HCC may be significantly influenced by dysregulated Wnt/β-catenin signaling. This article aimed to examine the pathway that controls Wnt signaling in HCC and its mechanisms. In addition, we highlighted the role of this pathway in HCC etiology and targeted treatment.
肝细胞癌（HCC）是全球最致命的恶性肿瘤之一，其发病率和死亡率逐年上升。HCC研究越来越集中于了解其发病机制并开发治疗方法。Wnt信号通路是一个复杂且在进化上保守的信号转导系统，已在多种恶性肿瘤的发生和治疗中得到广泛研究。最近的研究表明，Wnt/β-连环蛋白信号失调可能会显著影响HCC的发病机制。本文旨在研究HCC中控制Wnt信号的途径及其机制。此外，我们强调了该途径在HCC病因学和靶向治疗中的作用。
