成纤维细胞：起源、定义及在健康和疾病中的功能。
Fibroblasts: Origins, definitions, and functions in health and disease.
机构信息
Department of Developmental and Cell Biology, University of California, Irvine, Irvine, CA 92697, USA; Sue and Bill Gross Stem Cell Research Center, University of California, Irvine, Irvine, CA 92697, USA; NSF-Simons Center for Multiscale Cell Fate Research, University of California, Irvine, Irvine, CA 92697, USA; Center for Complex Biological Systems, University of California, Irvine, Irvine, CA 92697, USA.
Department of Developmental and Cell Biology, University of California, Irvine, Irvine, CA 92697, USA; Sue and Bill Gross Stem Cell Research Center, University of California, Irvine, Irvine, CA 92697, USA; NSF-Simons Center for Multiscale Cell Fate Research, University of California, Irvine, Irvine, CA 92697, USA.
出版信息
Cell. 2021 Jul 22;184(15):3852-3872. doi: 10.1016/j.cell.2021.06.024.
Fibroblasts are diverse mesenchymal cells that participate in tissue homeostasis and disease by producing complex extracellular matrix and creating signaling niches through biophysical and biochemical cues. Transcriptionally and functionally heterogeneous across and within organs, fibroblasts encode regional positional information and maintain distinct cellular progeny. We summarize their development, lineages, functions, and contributions to fibrosis in four fibroblast-rich organs: skin, lung, skeletal muscle, and heart. We propose that fibroblasts are uniquely poised for tissue repair by easily reentering the cell cycle and exhibiting a reversible plasticity in phenotype and cell fate. These properties, when activated aberrantly, drive fibrotic disorders in humans.
成纤维细胞是一种多样化的间充质细胞，通过产生复杂的细胞外基质并通过生物物理和生化线索创建信号小生境，参与组织稳态和疾病。在器官之间和内部，成纤维细胞在转录和功能上具有异质性，编码区域位置信息并维持独特的细胞后代。我们总结了它们在四个富含成纤维细胞的器官（皮肤、肺、骨骼肌和心脏）中的发育、谱系、功能和对纤维化的贡献。我们提出，成纤维细胞通过轻易重新进入细胞周期并表现出表型和细胞命运的可逆可塑性，从而为组织修复做好了独特的准备。这些特性在异常激活时会导致人类的纤维化疾病。
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