Suyama Kaori, Sakai Daisuke, Watanabe Masahiko
Department of Anatomy and Cellular Biology, Basic Medical Science, Tokai University School of Medicine, Isehara, Japan.
Department of Orthopaedic Surgery, Surgical Science, Tokai University School of Medicine, Isehara, Japan.
Front Cell Dev Biol. 2022 Mar 3;10:857164. doi: 10.3389/fcell.2022.857164. eCollection 2022.
It has been reported that degenerated and herniated lumbar intervertebral discs show high expression of IL-17, suggesting that local immune reactions occur in patients with low back pain. While clinical sample analyses from different laboratories confirm this, it is not deeply not known on how IL-17 is induced in the pathology and their interactions with other inflammatory responses. This conscience review organizes current laboratory findings on this topic and present trajectory for full understanding on the role of IL-17 in pathology of intervertebral disc disease.
据报道，退变和突出的腰椎间盘显示出白细胞介素-17（IL-17）的高表达，这表明下腰痛患者存在局部免疫反应。虽然不同实验室的临床样本分析证实了这一点，但对于IL-17在病理过程中是如何被诱导的以及它们与其他炎症反应的相互作用，目前还知之甚少。这篇综述整理了关于该主题的当前实验室研究结果，并提出了全面理解IL-17在椎间盘疾病病理中作用的研究方向。
