Wu Yuhao, Shen Shiwei, Shi Yifeng, Tian Naifeng, Zhou Yifei, Zhang Xiaolei
Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
The Second School of Medicine, Wenzhou Medical University, Wenzhou, China.
Front Bioeng Biotechnol. 2022 Mar 2;10:823945. doi: 10.3389/fbioe.2022.823945. eCollection 2022.
Intervertebral disc degeneration (IVDD) is the main cause of cervical and lumbar spondylosis. Over the past few years, the relevance between cellular senescence and IVDD has been widely studied, and the senescence-associated secretory phenotype (SASP) produced by senescent cells is found to remodel extracellular matrix (ECM) metabolism and destruct homeostasis. Elimination of senescent cells by senolytics and suppression of SASP production by senomorphics/senostatics are effective strategies to alleviate degenerative diseases including IVDD. Here, we review the involvement of senescence in the process of IVDD; we also discuss the potential of senolytics on eliminating senescent disc cells and alleviating IVDD; finally, we provide a table listing senolytic drugs and small molecules, aiming to propose potential drugs for IVDD therapy in the future.
椎间盘退变（IVDD）是颈椎病和腰椎病的主要病因。在过去几年中，细胞衰老与IVDD之间的相关性已得到广泛研究，并且发现衰老细胞产生的衰老相关分泌表型（SASP）会重塑细胞外基质（ECM）代谢并破坏内环境稳态。通过衰老细胞溶解剂清除衰老细胞以及通过衰老相关表型调节剂/衰老抑制剂抑制SASP产生是缓解包括IVDD在内的退行性疾病的有效策略。在此，我们综述衰老在IVDD过程中的作用；我们还讨论了衰老细胞溶解剂在消除衰老椎间盘细胞和缓解IVDD方面的潜力；最后，我们提供了一个列出衰老细胞溶解药物和小分子的表格，旨在为未来IVDD治疗提出潜在药物。
