芯片大脑：梦想还是现实？ - Suppr

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Brain-on-a-Chip: Dream or Reality?

作者信息

Brofiga Martina, Massobrio Paolo

机构信息

Department of Informatics, Bioengineering, Robotics, Systems Engineering (DIBRIS), University of Genova, Genova, Italy.

ScreenNeuroPharm, Sanremo, Italy.

出版信息

Front Neurosci. 2022 Mar 2;16:837623. doi: 10.3389/fnins.2022.837623. eCollection 2022.

DOI:10.3389/fnins.2022.837623

PMID:35310088

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8924512/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/882b/8924512/f8626c7a986a/fnins-16-837623-g0001.jpg

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On the road to the brain-on-a-chip: a review on strategies, methods, and applications.

J Neural Eng. 2021 Aug 12;18(4). doi: 10.1088/1741-2552/ac15e4.

Mapping human brain organoids on a spatial atlas.

Cell Stem Cell. 2021 Jun 3;28(6):983-984. doi: 10.1016/j.stem.2021.05.004.

Neurospheres: a potential in vitro model for the study of central nervous system disorders.

Mol Biol Rep. 2021 Apr;48(4):3649-3663. doi: 10.1007/s11033-021-06301-4. Epub 2021 Mar 25.

Three-dimensional, multifunctional neural interfaces for cortical spheroids and engineered assembloids.

Sci Adv. 2021 Mar 17;7(12). doi: 10.1126/sciadv.abf9153. Print 2021 Mar.

3D high-density microelectrode array with optical stimulation and drug delivery for investigating neural circuit dynamics.

Nat Commun. 2021 Jan 21;12(1):492. doi: 10.1038/s41467-020-20763-3.

Generation of Functional Human 3D Cortico-Motor Assembloids.

Cell. 2020 Dec 23;183(7):1913-1929.e26. doi: 10.1016/j.cell.2020.11.017. Epub 2020 Dec 16.

Brain-on-a-chip: A history of development and future perspective.

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