Wright S J, Keating M J
University of Texas, M.D. Anderson Cancer Center, Houston, USA.
Leuk Lymphoma. 1995 Dec;20(1-2):131-6. doi: 10.3109/10428199509054764.
The association of hemolytic anemia and other autoimmune cytopenias with chronic lymphocytic leukemia (CLL) is well known. The etiology of these immune syndromes is still uncertain, despite evidence that the putative cell of origin of the B-CLL cell produces naturally occurring autoantibodies. Cyclosporine A is effective in treating the immune manifestations associated with CLL and, occasionally, has shown anti-leukemic activity. We report two cases in which cyclosporine A treatment of autoimmune hemolytic anemia resulted in reduction of CLL cell burden. We then discuss the possible mechanism of action of cyclosporine A and the nature of the autoimmune processes involved.
溶血性贫血及其他自身免疫性血细胞减少症与慢性淋巴细胞白血病（CLL）的关联已广为人知。尽管有证据表明B - CLL细胞的假定起源细胞会产生天然存在的自身抗体，但这些免疫综合征的病因仍不明确。环孢素A可有效治疗与CLL相关的免疫表现，且偶尔还显示出抗白血病活性。我们报告了两例使用环孢素A治疗自身免疫性溶血性贫血后CLL细胞负荷减轻的病例。然后我们讨论了环孢素A可能的作用机制以及所涉及的自身免疫过程的性质。
