Overton Marieclaire, Pihlsgård Mats, Elmståhl Sölve
Division of Geriatric Medicine Department of Clinical Sciences in Malmö Lund University Skåne University Hospital Malmö Sweden.
Perinatal and Cardiovascular Epidemiology Lund University Skåne University Hospital Malmö Sweden.
Alzheimers Dement (N Y). 2022 Mar 14;8(1):e12260. doi: 10.1002/trc2.12260. eCollection 2022.
Research suggests that incident dementia is decreasing, yet research on secular trends of prodromal dementia such as mild cognitive impairment (MCI) is lacking.
To determine change of MCI prevalence over time and potential explanatory factors, four baseline samples (years 2001-2020) of Swedish participants ( = 3910) aged 60 and 81 at examination were compared.
An overall drop of 9 to 10 percentage points in MCI prevalence between 2001 and 2020 was observed, with lower odds ratios (OR) for MCI in the latest birth cohorts compared to earliest (e.g., ORs for 60-year-olds in latest born = 0.53; 95% confidence interval [CI] 0.37-0.76). Adjustments for sociodemographic (e.g., education), lifestyle, vascular and metabolic health and depression could not fully explain the observed MCI decline (e.g., 60-year-olds, OR = 0.59; 95% CI 0.40-0.88).
Studies like this are imperative as even a slight postponement in the onset of dementia could have a substantial impact on future public health burden.
研究表明,新发痴呆症的发病率正在下降,但对于前驱性痴呆(如轻度认知障碍,MCI)的长期趋势研究却很缺乏。
为了确定MCI患病率随时间的变化以及潜在的解释因素,对瑞典参与者(n = 3910)在2001年至2020年期间的四个基线样本进行了比较,这些参与者在检查时年龄为60至81岁。
观察到2001年至2020年期间MCI患病率总体下降了9至10个百分点,与最早出生队列相比,最新出生队列中MCI的比值比(OR)较低(例如,60岁人群中最新出生队列的OR = 0.53;95%置信区间[CI] 0.37 - 0.76)。对社会人口统计学(如教育程度)、生活方式、血管和代谢健康以及抑郁状况进行调整后,仍无法完全解释观察到的MCI患病率下降情况(例如,60岁人群,OR = 0.59;95% CI 0.40 - 0.88)。
这样的研究至关重要,因为即使痴呆症发病的轻微推迟也可能对未来的公共卫生负担产生重大影响。