结肠憩室出血患者一年内再出血的危险因素。
Risk factors of re-bleeding within a year in colonic diverticular bleeding patients.
作者信息
Gonai Takahiro, Toya Yosuke, Kawasaki Keisuke, Yanai Shunichi, Akasaka Risaburo, Nakamura Shotaro, Matsumoto Takayuki
机构信息
Division of Gastroenterology, Department of Internal Medicine, School of Medicine Iwate Medical University Iwate Japan.
出版信息
DEN Open. 2021 Aug 25;2(1):e22. doi: 10.1002/deo2.22. eCollection 2022 Apr.
BACKGROUND/AIMS: Although colonic diverticular bleeding (CDB) is common, few reports have described the effects of antithrombotic agents (ATs) on CDB. This study aimed to clarify the risk factors of re-bleeding within a year in CDB patients.
METHODS
We retrospectively analyzed the risk of re-bleeding in CDB patients. Among 324 patients who were hospitalized for acute lower gastrointestinal bleeding at our institution during the period from 2015 to 2019, we used 76 patients who were diagnosed as CDB. Risk factors for re-bleeding were determined by Cox proportional hazard models.
RESULTS
Of 76 patients analyzed, 32 were taking ATs, nine of whom were taking multiple agents. Twenty-six patients re-bled within a year. Compared with the patients without re-bleeding, patients with re-bleeding within a year had been treated by antithrombotic therapy more frequently (62% vs. 32%, = 0.013). Cox proportional hazard model revealed that treatment with ATs (hazard ratio 3.89, 95% confidence interval 1.53-10.74, = 0.004) was an independent risk factor for re-bleeding within a year.
CONCLUSION
ATs were found to be an independent risk factor related to re-bleeding within a year in patients with CDB.
背景/目的：尽管结肠憩室出血（CDB）很常见，但很少有报告描述抗血栓药物（ATs）对CDB的影响。本研究旨在阐明CDB患者一年内再出血的危险因素。
方法
我们回顾性分析了CDB患者再出血的风险。在2015年至2019年期间因急性下消化道出血在我院住院的324例患者中，我们选取了76例被诊断为CDB的患者。通过Cox比例风险模型确定再出血的危险因素。
结果
在分析的76例患者中，32例正在服用ATs，其中9例服用多种药物。26例患者在一年内再次出血。与未再出血的患者相比，一年内再出血的患者接受抗血栓治疗的频率更高（62%对32%，P = 0.013）。Cox比例风险模型显示，使用ATs治疗（风险比3.89，95%置信区间1.53 - 10.74，P = 0.004）是一年内再出血的独立危险因素。
结论
发现ATs是CDB患者一年内再出血的独立危险因素。
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