绝经后女性血清骨保护素水平及骨密度的评估

Evaluation of the serum level of osteoprotegerin and bone mineral density in postmenopausal women.

作者信息

Veshnavei Hossein Abdollahi

机构信息

School of Medicine, Isfahan University of Medical Sciences Isfahan, Iran.

出版信息

Int J Physiol Pathophysiol Pharmacol. 2022 Feb 15;14(1):10-15. eCollection 2022.

PMID:35310860

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8918604/

Abstract

OBJECTIVES

Women might face different issues after menopause. Reduction in bone mineral density (BMD) is one of these problems that put a heavy burden on the healthcare system, especially in developing countries. Studies assume that along with increased age, lack of physical activity and hormonal issues, some other factors might take part in this process. Osteoprotegerin (OPG) is one of the assumed factors. Here we aimed to assess the relation between serum levels of OPG and BMD in postmenopausal women.

METHODS

In this prospective cross-sectional study, 90 postmenopausal women were entered. Our cases were divided based on former medical documents into two groups of osteoporotic women (n=45) and healthy women (n=45). All cases were then analyzed using Dual-energy X-ray absorptiometry (DXA) and BMD and T-score were assessed for each case in different sites. Serum levels of OPG were also assessed using Enzyme-linked immunosorbent assay (ELISA). Data were then analyzed using SPSS software.

RESULTS

There were higher OPG levels in osteoporotic women compared with healthy women (P<0.001). We also indicated a significant difference in BMD between two groups of postmenopausal women in different sites (i.e. lumbar vertebrae L2-L4, trochanters, femoral neck and hip). We showed there is a reverse relation between serum OPG levels and BMD in lumbar vertebrae (r=-0.4, P=0.002), hip (r=-0.3, P=0.03) and femoral neck (r=-0.3, P=0.02) in both groups. There is a reverse relation between BMD and serum levels of OPG in postmenopausal women.

CONCLUSION

OPG levels are higher in osteoporotic women and have a reverse relation with BMD.

摘要

目的

绝经后女性可能面临不同问题。骨矿物质密度（BMD）降低是其中一个给医疗系统带来沉重负担的问题，在发展中国家尤为如此。研究认为，除年龄增长、缺乏体育活动和激素问题外，一些其他因素可能也参与了这一过程。骨保护素（OPG）就是其中一个被认为的因素。在此，我们旨在评估绝经后女性血清OPG水平与BMD之间的关系。

方法

在这项前瞻性横断面研究中，纳入了90名绝经后女性。根据既往病历将我们的研究对象分为两组，骨质疏松女性组（n = 45）和健康女性组（n = 45）。然后对所有研究对象使用双能X线吸收法（DXA）进行分析，并评估每个研究对象不同部位的BMD和T值。还使用酶联免疫吸附测定（ELISA）评估血清OPG水平。然后使用SPSS软件对数据进行分析。

结果

骨质疏松女性的OPG水平高于健康女性（P < 0.001）。我们还指出，两组绝经后女性在不同部位（即腰椎L2 - L4、大转子、股骨颈和髋部）的BMD存在显著差异。我们发现，两组中腰椎（r = -0.4，P = 0.002）、髋部（r = -0.3，P = 0.03）和股骨颈（r = -0.3，P = 0.02）的血清OPG水平与BMD呈负相关。绝经后女性的BMD与血清OPG水平呈负相关。