Beijing Laboratory of Biomedical Materials, State Key Laboratory of Organic-Inorganic Composites, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China.
ACS Appl Mater Interfaces. 2022 Mar 30;14(12):14668-14676. doi: 10.1021/acsami.2c03172. Epub 2022 Mar 21.
Near-infrared (NIR) light-triggered shape memory polymers are expected to have a more promising prospect in biomedical applications compared with traditional heat-triggered shape memory polymers. In this work, a new kind of polyurethane with NIR light-triggered shape memory property was prepared by using polycaprolactone (PCL), polydopamine nanoparticles (PDANPs), hexamethylene diisocyanate (HDI), and 1,4-butanediol (BDO). The synthesized PCL-PDA polyurethanes, especially when the weight content of PDANPs was 0.17%, showed excellent mechanical properties because the PDANPs were well-dispersed in polyurethanes by the chain extension reaction. Moreover, it also showed an NIR light-triggered rapid shape recovery because of the photothermal effect of polydopamine. The in vitro and in vivo tests showed that the PCL-PDA polyurethane would not inhibit cell proliferation nor induce a strong host inflammatory response, revealing the non-cytotoxicity and good biocompatibility of the material. In addition, the PCL-PDA polyurethane exhibited excellent in vivo NIR light-triggered shape memory performance under an 808 nm laser with low intensity (0.33 W cm), which was harmless to the human skin. These results demonstrated the potential of the PCL-PDA polyurethane in biomedical implant applications.
近红外（NIR）光触发形状记忆聚合物有望在生物医学应用中比传统的热触发形状记忆聚合物具有更广阔的前景。在这项工作中，通过使用聚己内酯（PCL）、聚多巴胺纳米粒子（PDANPs）、六亚甲基二异氰酸酯（HDI）和 1,4-丁二醇（BDO），制备了一种具有 NIR 光触发形状记忆性能的新型聚氨酯。合成的 PCL-PDA 聚氨酯，尤其是当 PDANPs 的重量含量为 0.17%时，由于 PDANPs 通过链延长反应在聚氨酯中得到了很好的分散，因此表现出优异的机械性能。此外，由于聚多巴胺的光热效应，它还表现出 NIR 光触发的快速形状恢复。体外和体内试验表明，PCL-PDA 聚氨酯不会抑制细胞增殖，也不会引起强烈的宿主炎症反应，显示出材料的非细胞毒性和良好的生物相容性。此外，PCL-PDA 聚氨酯在强度为 0.33 W cm 的 808nm 激光下表现出出色的体内 NIR 光触发形状记忆性能，对人体皮肤无害。这些结果表明 PCL-PDA 聚氨酯在生物医学植入物应用中的潜力。
