Polydopamine Nanoparticle-Reinforced Near-Infrared Light-Triggered Shape Memory Polycaprolactone-Polydopamine Polyurethane for Biomedical Implant Applications.

Near-infrared (NIR) light-triggered shape memory polymers are expected to have a more promising prospect in biomedical applications compared with traditional heat-triggered shape memory polymers. In this work, a new kind of polyurethane with NIR light-triggered shape memory property was prepared by using polycaprolactone (PCL), polydopamine nanoparticles (PDANPs), hexamethylene diisocyanate (HDI), and 1,4-butanediol (BDO). The synthesized PCL-PDA polyurethanes, especially when the weight content of PDANPs was 0.17%, showed excellent mechanical properties because the PDANPs were well-dispersed in polyurethanes by the chain extension reaction. Moreover, it also showed an NIR light-triggered rapid shape recovery because of the photothermal effect of polydopamine. The in vitro and in vivo tests showed that the PCL-PDA polyurethane would not inhibit cell proliferation nor induce a strong host inflammatory response, revealing the non-cytotoxicity and good biocompatibility of the material. In addition, the PCL-PDA polyurethane exhibited excellent in vivo NIR light-triggered shape memory performance under an 808 nm laser with low intensity (0.33 W cm), which was harmless to the human skin. These results demonstrated the potential of the PCL-PDA polyurethane in biomedical implant applications.