School of Ophthalmology and Optometry, School of Biomedical Engineering, Wenzhou Medical University, Wenzhou, Zhejiang 325027, China; Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, Zhejiang 325011, China.
Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, Zhejiang 325011, China.
Colloids Surf B Biointerfaces. 2023 Dec;232:113590. doi: 10.1016/j.colsurfb.2023.113590. Epub 2023 Oct 13.
Uncontrolled expansion of shape memory sponges face a significant challenge in the treatment of lethal incompressible hemorrhage, which can lead to blood overflow or damage to the surrounding tissue. Herein, we developed a polydopamine functionalized polyurethane shape memory sponge (PDA-TPI-PU) with a controllable degree of expansion by near-infrared (NIR) light-triggered stimulation for the treatment of incompressible hemorrhage. The sponge has excellent liquid absorption performance and robust mechanical strength as well as good photothermal conversion ability. Under NIR light of 0.32 W/cm, the maximum recovery rate of the fixed-shape compression sponge was 91% within 25 s in air and 80% within 25 s in blood. In the SD rat liver penetrating injury model, compared with commercial medical gelatin sponge and PVA sponge, the PDA-TPI-PU sponge could effectively control the bleeding under the NIR light irradiation and did not cause excessive compression of the wound. The sponge with these characteristics shows potential application prospects as a hemostatic material.
形状记忆海绵的失控扩张在治疗致命的不可压缩性出血方面面临着重大挑战，这可能导致血液溢出或周围组织损伤。在此，我们开发了一种具有近红外（NIR）光触发刺激可控扩张程度的聚多巴胺功能化聚氨酯形状记忆海绵（PDA-TPI-PU），用于治疗不可压缩性出血。该海绵具有优异的液体吸收性能和强大的机械强度，以及良好的光热转换能力。在 0.32 W/cm 的近红外光下，固定形状压缩海绵在空气中 25 秒内的最大回复率为 91%，在血液中 25 秒内的最大回复率为 80%。在 SD 大鼠肝脏穿透损伤模型中，与商业医用明胶海绵和 PVA 海绵相比，PDA-TPI-PU 海绵在近红外光照射下能有效控制出血，且不会对伤口造成过度压迫。这种具有可控扩张程度的海绵作为一种止血材料具有潜在的应用前景。
