Department of Pathology, Indiana University School of Medicine, Indianapolis, IN, USA.
Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Am J Clin Pathol. 2022 Aug 4;158(2):235-241. doi: 10.1093/ajcp/aqac033.
SATB2 is a transcriptional regulator that plays an important role in osteoblastic differentiation. We examined the prevalence and potential significance of SATB2 expression in undifferentiated pleomorphic sarcoma (UPS) of bone.
We examined 38 cases of bone UPS without osteoid. The male-to-female ratio was 1:1.4, with a median age of 48 years (range, 23-83 years). Tumors occurred primarily in the femur (n = 8) and ilium (n = 8), with a median tumor size of 9.5 cm (range, 1.8-27.0 cm). The median follow-up was 24.7 months (range, 2-82 months): 11 patients developed local recurrences, and 18 patients had metastases, mainly to lung and bone.
SATB2 expression (nuclear labeling ≥5%) was seen in 21 of 38 (55%) cases: 5 with focal (nuclear labeling 5%), 11 with patchy (nuclear labeling 5%-50%), and 5 with diffuse (nuclear labeling ≥50%) staining. Among this group, diffuse SATB2 expression demonstrated superior metastasis-free survival (P = .036) and event-free survival (P = .024). For comparison, 100 soft tissue UPS were stained; the majority were negative (75/100 [75%]).
UPS of bone demonstrated more frequent SATB2 expression compared with its soft tissue counterpart. In this series, diffuse SATB2 expression in UPS of bone was associated with better outcomes. Additional studies are still needed to determine its significance.
SATB2 是一种转录调节因子，在成骨细胞分化中发挥重要作用。我们研究了 SATB2 在骨未分化多形性肉瘤（UPS）中的表达频率及其潜在意义。
我们检查了 38 例无骨样组织的骨 UPS 病例。男女比例为 1:1.4，中位年龄为 48 岁（范围 23-83 岁）。肿瘤主要发生于股骨（n=8）和髋骨（n=8），肿瘤大小中位数为 9.5cm（范围 1.8-27.0cm）。中位随访时间为 24.7 个月（范围 2-82 个月）：11 例患者出现局部复发，18 例患者发生转移，主要转移部位为肺和骨。
38 例中 21 例（55%）SATB2 表达（核标记≥5%）：5 例为局灶性（核标记 5%），11 例为斑片状（核标记 5%-50%），5 例为弥漫性（核标记≥50%）染色。在这一组中，弥漫性 SATB2 表达显示出更好的无转移生存（P=0.036）和无事件生存（P=0.024）。为了比较，我们对 100 例软组织 UPS 进行了染色；大多数为阴性（75/100 [75%]）。
与软组织 UPS 相比，骨 UPS 中 SATB2 的表达更为频繁。在本系列中，骨 UPS 中弥漫性 SATB2 表达与更好的结果相关。仍需要进一步的研究来确定其意义。
