Medical Affairs and Innovation, Héma-Québec, Québec, Canada.
Biochemistry, Microbiology and Bio-informatics, Université Laval, Québec, Canada.
Vox Sang. 2022 Jul;117(7):879-886. doi: 10.1111/vox.13272. Epub 2022 Mar 21.
Platelet components are commonly transfused to patients for a variety of indications, including patients with low platelet counts or patients with platelet dysfunction who are bleeding or at high risk of bleeding. Although the risk of pathogen contamination of platelet components has declined significantly over the last 40 years, it remains a concern for the patients, for blood banks and for physicians. Pathogen inactivation (PI) technologies have been developed to mitigate this risk. This review focuses on the residual risks of transfusion-transmitted bacterial infections by platelet transfusion after PI. We describe and assess the relationship between the bacterial load and the timing and capacity of reduction of the different PI technologies, as well as the risks that could represent spore-forming microorganisms and the possible introduction of microorganisms after PI.
血小板成分通常被输注给各种适应证的患者，包括血小板计数低或有血小板功能障碍、正在出血或有高出血风险的患者。尽管过去 40 年来血小板成分病原体污染的风险已显著下降，但它仍然是患者、血库和医生关注的问题。病原体灭活 (PI) 技术的发展降低了这种风险。本综述重点介绍了 PI 后血小板输注传播细菌感染的残余风险。我们描述并评估了不同 PI 技术的细菌负荷与减少时间和能力之间的关系，以及芽孢形成微生物可能带来的风险和 PI 后微生物的可能引入。
