Bottino Emanuel, Ponce Andrés Alberto
Cátedra de Fisiología Humana, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba.
Cátedra de Fisiología Humana, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba .
Rev Fac Cien Med Univ Nac Cordoba. 2022 Mar 7;79(1):33-42. doi: 10.31053/1853.0605.v79.n1.30642.
The emerging infection caused by the new SARS-CoV-2 coronavirus has become a real challenge for the scientific community. Currently, there is little knowledge about the pathogenesis of COVID-19 and in recent times the participation of the host's own immune response in the progression of the disease has been proposed. Innate pulmonary immunity is the first barrier against different toxins, which can cause tissue damage, with the consequent alteration of respiratory function. However, a loss in the regulation of these inflammatory mechanisms can cause a disruption in the homeostasis of the affected tissue.
To evaluate the role of the pulmonary innate immune response in the pathogenesis of COVID-19. : Results: A global alteration of the pulmonary innate immune response was found in SARS-CoV-2 infection, which would have relevance in the pathogenesis of COVID-19.
A systematic review of studies published in scientific search engines was carried out: PubMed, Google Scholar, Science Direct. The following keywords were used: “COVID-19”; "Acute Respiratory Distress Syndrome"; "SARS-CoV-2"; "Innate pulmonary immunity"; "Innate immune response".
The global involvement of the innate immune response and consequently of lung tissue homeostasis, in SARS-CoV-2 infection, requires the design of new therapeutic strategies aimed at modulating the altered pro-inflammatory mechanisms in COVID-19.
新型严重急性呼吸综合征冠状病毒2（SARS-CoV-2）引发的新发感染已成为科学界面临的一项现实挑战。目前，关于2019冠状病毒病（COVID-19）的发病机制知之甚少，近来有人提出宿主自身免疫反应在该疾病进展过程中的作用。肺部固有免疫是抵御不同毒素的第一道防线，这些毒素可导致组织损伤，进而引起呼吸功能改变。然而，这些炎症机制调节功能的丧失可导致受影响组织的内环境稳态遭到破坏。
评估肺部固有免疫反应在COVID-19发病机制中的作用。
在SARS-CoV-2感染中发现肺部固有免疫反应出现整体改变，这可能与COVID-19的发病机制相关。
对科学搜索引擎（PubMed、谷歌学术、科学Direct）上发表的研究进行系统综述。使用了以下关键词：“COVID-19”；“急性呼吸窘迫综合征”；“SARS-CoV-2”；“肺部固有免疫”；“固有免疫反应”。
在SARS-CoV-2感染中，固有免疫反应以及肺组织内环境稳态的整体受累，需要设计新的治疗策略来调节COVID-19中发生改变的促炎机制。
