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关于严重急性呼吸综合征冠状病毒2(SARS-CoV-2)生物学、流行病学、诊断及潜在管理方案的综合综述

The Inclusive Review on SARS-CoV-2 Biology, Epidemiology, Diagnosis, and Potential Management Options.

作者信息

Beig Parikhani Arezoo, Bazaz Masoume, Bamehr Hadi, Fereshteh Sepideh, Amiri Shahin, Salehi-Vaziri Mostafa, Arashkia Arash, Azadmanesh Kayhan

机构信息

Department of Medical Biotechnology, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran.

Department of Bacteriology, Pasteur Institute of Iran, Tehran, Iran.

出版信息

Curr Microbiol. 2021 Apr;78(4):1099-1114. doi: 10.1007/s00284-021-02396-x. Epub 2021 Feb 27.

DOI:10.1007/s00284-021-02396-x
PMID:33638671
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7913045/
Abstract

A novel coronavirus member was reported in Wuhan City, Hubei Province, China, at the end of the year 2019. Initially, the infection spread locally, affecting the Wuhan people, and then expanded rapidly throughout the world. On 11 March 2020, the World Health Organization (WHO) proclaimed it a global pandemic. The virus is a new strain most closely related to a bat coronavirus (RaTG13) which was not previously discovered in humans and is now formally known as the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Coronavirus disease 2019 (COVID-19) is the disease syndrome that the SARS-CoV-2 virus triggers. It is suggested that SARS-CoV-2 can be transmitted through aerosols, direct/indirect contact, and also during medical procedures and specimen handling. The infection is characterized by isolated flu-like symptoms, but there may be specific signs of fever, fatigue, cough, and shortness of breath, as well as the loss of smell and breathing difficulty. Within this report, we tried to review the most current scientific literature published by January 2021 on various aspects of the outbreak, including virus structure, pathogenesis, clinical presentation, epidemiology, diagnostic approaches, potential therapeutics and vaccines, and prospects. We hope this article makes a beneficial impact on public education to better deal with the SARS-CoV-2 crisis and push a step forward in the near term towards its prevention and control.

摘要

2019年底,中国湖北省武汉市报告了一种新型冠状病毒成员。最初,感染在当地传播,影响武汉市民,随后迅速蔓延至全球。2020年3月11日,世界卫生组织(WHO)宣布其为全球大流行病。该病毒是一种新毒株,与一种此前未在人类中发现的蝙蝠冠状病毒(RaTG13)关系最为密切,现在被正式命名为严重急性呼吸综合征冠状病毒2(SARS-CoV-2)。2019冠状病毒病(COVID-19)是SARS-CoV-2病毒引发的疾病综合征。有人认为,SARS-CoV-2可通过气溶胶、直接/间接接触传播,也可在医疗程序和标本处理过程中传播。感染的特征是出现类似流感的孤立症状,但可能有发热、乏力、咳嗽、气短等特定症状,以及嗅觉丧失和呼吸困难。在本报告中,我们试图回顾截至2021年1月发表的关于此次疫情各方面的最新科学文献,包括病毒结构、发病机制、临床表现、流行病学、诊断方法、潜在治疗方法和疫苗以及前景。我们希望本文能对公众教育产生有益影响,以便更好地应对SARS-CoV-2危机,并在短期内朝着预防和控制该病毒迈进一步。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45cb/7913045/f1b3e1da1a9b/284_2021_2396_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45cb/7913045/f1b3e1da1a9b/284_2021_2396_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45cb/7913045/f1b3e1da1a9b/284_2021_2396_Fig2_HTML.jpg

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