Wang Su Han, Ma Ning, Zang Xiao Huan, Zhang Shuai Hua, Wang Jian Ping, Wu Ning Peng
College of Veterinary Medicine, Hebei Agricultural University, Baoding, PR China.
College of Science, Hebei Agricultural University, Baoding, PR China.
Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2022 May;39(5):901-911. doi: 10.1080/19440049.2022.2037728. Epub 2022 Mar 21.
A graphitic carbon nitride was synthesised and nalidixic acid (NA) based molecularly imprinted microspheres (MIMs) were polymerised on its surface to create a composite material. After characterisation and evaluation of its absorption ability, the composite was used to prepare a solid-phase extraction (SPE) cartridge for purification of fluoroquinolones in chicken muscle, analysed by ultra-performance liquid chromatography. The cartridge showed high absorption capacities (378-559 μg) and high recoveries (92.1-99.4%) for eight fluoroquinolones, and could be reused at least 20 times. The limits of detection for the 8 drugs were 0.2-0.8 ng g, and recoveries from standard fortified blank chicken muscle samples were 71.9-96.8%. This is the first study reporting the use of molecularly imprinted graphitic carbon nitride composite to determine the residue of veterinary drug in foods of animal origin.
合成了一种石墨相氮化碳，并在其表面聚合了基于萘啶酸（NA）的分子印迹微球（MIMs），以制备一种复合材料。在对其吸附能力进行表征和评估后，该复合材料被用于制备固相萃取（SPE）柱，用于净化鸡肉中的氟喹诺酮类药物，并通过超高效液相色谱进行分析。该柱对8种氟喹诺酮类药物表现出高吸附容量（378 - 559μg）和高回收率（92.1 - 99.4%），并且可以重复使用至少20次。8种药物的检测限为0.2 - 0.8 ng/g，在标准添加的空白鸡肉样品中的回收率为71.9 - 96.8%。这是第一项报道使用分子印迹石墨相氮化碳复合材料测定动物源性食品中兽药残留的研究。
