Identification of inbred strains of mice: II. Characterization of different substrains of the C3H strain.

Substrains of inbred C3H mice differ significantly in their genetic constitution with respect to biochemical markers, skin grafting, and skeletal variations. The presence of such discrepancies among substrains poses a problem when comparing conclusions based on experiments done in different substrains. Therefore, methods of controlling the genetic constitution are necessary and important to avoid these discrepancies.