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盆腔器官脱垂常规手术后的长期结局——一项基于全国登记册的队列研究

Long-term outcome after routine surgery for pelvic organ prolapse-A national register-based cohort study.

作者信息

Nüssler Emil, Granåsen Gabriel, Bixo Marie, Löfgren Mats

机构信息

Department of Clinical Sciences, Obstetrics and Gynaecology, Umeå University, 901 85, Umeå, Sweden.

出版信息

Int Urogynecol J. 2022 Jul;33(7):1863-1873. doi: 10.1007/s00192-022-05156-y. Epub 2022 Mar 21.

DOI:10.1007/s00192-022-05156-y
PMID:35312802
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9270303/
Abstract

INTRODUCTION AND HYPOTHESIS

Pelvic organ prolapse (POP) is common, and women have an estimated 12-19% lifetime risk for needing POP surgery. Aims were to measure re-operation rates up to 10 years after POP surgery and patient-reported outcomes (PROMs) 5 years after a first-time operation for POP.

METHODS

This is a cohort study using the Swedish National Quality Register for Gynaecological Surgery (GynOp). We retrieved information from 32,086 POP-operated women up to 10 years later. After validation, a web-based PROM questionnaire was sent to 4380 women who 5 years previously had standard POP surgery. Main outcome measures were reoperations due to a relapse of prolapse and PROMs 5 years after the primary operation.

RESULTS

Among women operated for all types of POP, 11% had re-operations 5 years later and an additional 4% 10 years later, with similar frequencies for various compartments/types of surgery. PROMs yielded a 75% response rate after 5 years. Cure rate was 68% for anterior, 70% for posterior, and 74% for combined anterior-posterior native repairs. Patient satisfaction exceeded 70%, and symptom reduction was still significant after 5 years (p < 0.0001).

CONCLUSIONS

Following primary prolapse surgery, re-operation rates are low, even after 10 years. A web-based survey for follow-up of PROMs after POP surgery is feasible and yields a high response rate after 5 years. The subjective cure rate after primary POP operations is high, with reduced symptoms and satisfied patients regardless of compartment. Standard prolapse surgery with native tissue repair produces satisfactory long-term results.

摘要

引言与假设

盆腔器官脱垂(POP)很常见,据估计女性一生中需要进行POP手术的风险为12%-19%。本研究旨在测量POP手术后长达10年的再次手术率以及首次POP手术后5年患者报告的结局(PROMs)。

方法

这是一项使用瑞典国家妇科手术质量登记册(GynOp)的队列研究。我们在长达10年后从32086名接受POP手术的女性中获取信息。经过验证后,向4380名5年前接受标准POP手术的女性发送了基于网络的PROM问卷。主要结局指标是因脱垂复发导致的再次手术以及初次手术后5年的PROMs。

结果

在接受各种类型POP手术的女性中,5年后11%的人进行了再次手术,10年后另有4%的人进行了再次手术,不同腔室/手术类型的频率相似。5年后PROMs的回复率为75%。前壁修复的治愈率为68%,后壁修复为70%,前后壁联合原位修复为74%。患者满意度超过70%,5年后症状减轻仍然显著(p<0.0001)。

结论

初次脱垂手术后,即使在10年后再次手术率也很低。基于网络的POP手术后PROMs随访调查是可行的,5年后回复率很高。初次POP手术后主观治愈率很高,无论腔室如何,症状均减轻且患者满意。采用原位组织修复的标准脱垂手术可产生令人满意的长期效果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aaa1/9270303/fd74bd4e492c/192_2022_5156_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aaa1/9270303/e10035bda2e0/192_2022_5156_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aaa1/9270303/bef82987de4d/192_2022_5156_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aaa1/9270303/c521d197c221/192_2022_5156_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aaa1/9270303/fd74bd4e492c/192_2022_5156_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aaa1/9270303/e10035bda2e0/192_2022_5156_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aaa1/9270303/bef82987de4d/192_2022_5156_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aaa1/9270303/c521d197c221/192_2022_5156_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aaa1/9270303/fd74bd4e492c/192_2022_5156_Fig4_HTML.jpg

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