Yu Xia, Lin Wenyi, Zheng Xuemei, He Li, Yang Zhenglin, Lin Yonghong
Department of Clinical Laboratory, Chengdu Women's and Children's Central Hospital, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.
Department of Medical Pathology, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.
Front Med (Lausanne). 2023 Jun 7;10:1158815. doi: 10.3389/fmed.2023.1158815. eCollection 2023.
At present, there is no feature description of the mechanism of pelvic organ prolapse (POP) in the literature. This study aimed to map the emerging trends regarding the mechanism of POP from inception to 2022 by bibliometric analysis and to analyze its research hotspots and frontiers.
We downloaded pertinent publications from inception to 2022 from the Web of Science Core Collection (WoSCC) on 30 June 2022. The data were then examined using the Bibliometrix program in R (Version 4.1.0), CiteSpace software, the Online Analysis Platform of Literature Metrology (https://bibliometric.com), and a bibliometrix online interface.
A total of 290 qualified records on the mechanism of POP were identified and included in the analysis. The most productive journal was International Urogynecology Journal. Bump RC and Olsen AL were the most cited authors. Extracellular matrix, collagen, apoptosis, elastin, oxidative stress, gene expression, matrix metalloproteinase, and tissue engineering were among the 25 most relevant terms. According to the analysis of trending topics, tissue engineering has become a new research hotspot.
Extracellular matrix remodeling, oxidative stress and apoptosis are the three main directions for studying the mechanism of POP. In addition, tissue engineering has become a new research hotspot. In the future, in-depth research on the interaction between different mechanisms will be carried out, and attempts will be made to combine biomimetic materials and seed cells to achieve the regeneration and reconstruction of POP-related organs.
目前，文献中尚无关于盆腔器官脱垂（POP）机制的特征描述。本研究旨在通过文献计量分析描绘从起始到2022年POP机制的新兴趋势，并分析其研究热点和前沿。
我们于2022年6月30日从科学网核心合集（WoSCC）下载了从起始到2022年的相关出版物。然后使用R（版本4.1.0）中的Bibliometrix程序、CiteSpace软件、文献计量在线分析平台（https://bibliometric.com）和Bibliometrix在线界面检查数据。
共识别出290条关于POP机制的合格记录并纳入分析。发文量最多的期刊是《国际尿控妇科杂志》。Bump RC和Olsen AL是被引次数最多的作者。细胞外基质、胶原蛋白、细胞凋亡、弹性蛋白、氧化应激、基因表达、基质金属蛋白酶和组织工程是25个最相关的术语。根据趋势主题分析，组织工程已成为一个新的研究热点。
细胞外基质重塑、氧化应激和细胞凋亡是研究POP机制的三个主要方向。此外，组织工程已成为一个新的研究热点。未来，将对不同机制之间的相互作用进行深入研究，并尝试将仿生材料和种子细胞结合起来，实现POP相关器官的再生和重建。
