Division of Obstetrics and Gynecology, Department of Clinical Science, Intervention and Technology, Karolinska Institutet and Karolinska University Hospital, 14186, Huddinge, Stockholm, Sweden.
Department of Life, Health and Environmental Sciences, University of L'Aquila, Via Vetoio, 67100, L'Aquila, Italy.
J Assist Reprod Genet. 2022 Apr;39(4):905-918. doi: 10.1007/s10815-022-02418-y. Epub 2022 Mar 21.
In mammalian species an optimal fertilization window during which successful fertilization occurs. In the majority of mammals estrus marks ovulation time and coincident with mating, thereby allowing the synchronized meeting in the fallopian tubes, between freshly ejaculated sperm and freshly ovulated oocytes. Conversely, women do not show natural visual signs of ovulation such that fertilization can occur hours later involving an aged oocyte and freshly ejaculated spermatozoa. During this time, the oocyte undergoes a rapid degradation known as "postovulatory aging" (POA). POA may become particularly important in the human-assisted reproductive technologies, as the fertilization of retrieved mature oocytes can be delayed due to increased laboratory workload or because of unforeseeable circumstances, like the delayed availability of semen samples. This paper is an updated review of the consequences of POA, either in vivo or in vitro, on oocyte quality with particular attention to modifications caused by POA on oocyte nuclear, cytoplasmic, genomic, and epigenetic maturation, and embryo development.
在哺乳动物物种中，存在一个最佳的受精窗口，在此期间受精会成功发生。在大多数哺乳动物中，发情标志着排卵时间，与交配同时发生，从而使刚射出的精子和刚排出的卵子在输卵管中同步相遇。相反，女性没有自然的排卵视觉迹象，因此受精可能会在数小时后发生，涉及到老化的卵子和刚射出的精子。在此期间，卵子会经历一种称为“排卵后老化”（POA）的快速降解。在人类辅助生殖技术中，POA 可能变得尤为重要，因为由于实验室工作量增加或由于不可预见的情况，如精液样本的延迟可用性，取回的成熟卵子的受精可能会被延迟。本文是对 POA 在体内或体外对卵子质量的影响的最新综述，特别关注 POA 对卵子核、质、基因组和表观遗传成熟以及胚胎发育的影响。
