基因多态性在复发性阿弗他口炎中的作用：一项系统评价和荟萃分析。
Role of genetic polymorphisms in recurrent aphthous stomatitis: A systematic review and meta-analysis.
作者信息
Yousefi Hila, Gholami Morteza, Zoughi Marziyeh, Rezaei Nima, Chuppani Aria, Nikfar Shekoufeh, Amoli Mahsa M
机构信息
Personalized Medicine Research Center, Endocrinology and Metabolism Clinical Sciences, Institute, Tehran University of Medical Sciences, Tehran, Iran.
Metabolic Disorders Research Centre, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Iran.
出版信息
Cytokine. 2022 May;153:155864. doi: 10.1016/j.cyto.2022.155864. Epub 2022 Mar 18.
Recurrent aphthous stomatitis (RAS) is one of the most common oral ulcerative diseases with unknown etiology. Identifying the genetic markers can improve medical care and prevention of RAS. Genetics variants inflammatory agents are associated with the risk of RAS. Thus, this meta-analysis aimed to investigate the genetic polymorphisms in RAS. Electronic literature search was carried out on Scopus, PubMed, and Web of Science (WOS). The references of relevant reviews were also manually checked. The observational studies till the end of 2020 were included. Odds ratio (OR) was estimated by fixed and random effect model. Seventeen polymorphisms in 23 studies were included in analysis. Pooled analysis performed for 12 polymorphisms (IL-2+166, IL-2-330, IL-4-590, IL-4 RA1902, IL-6-597, TNF-α-308, NLRP3(rs4612666, rs10754558), MMP2- rs2285053, MMP9- rs11697325, MMP9- rs3918242, MMP9- rs17576, IL-1a-889, IL-10-819, and IL-12+1188). The meta-analyses carried out for six polymorphisms (IL-1β-511, IL-1β+3954, IL-6-174, IL-10-592, IL-10-1082, and serotonin transporter). There were following significant results for IL-10, 819 in allelic:1.46(1.04-2.05) and homozygote: 1.61(1.08-2.39) models, serotonin Transporter in allelic:0.53(0.40-0.71), recessive:0.56(0.35-0.90), dominant:0.35(0.22-0.57) and homozygote:0.30(0.17-0.54) models. IL-1β-511 in dominant 0.69(0.50-0.95) and overdominant 0.73(0.55-0.96) models, IL-1β+3954 in allelic 1.25(1.05-1.50), homozygote 1.67(1.05-2.63) and dominant 1.26(1.01-1.57) models, IL-6-174 in dominant 2.24(1.36-3.67), IL-10-592 in homozygote 0.41(0.23-0.72) and dominant 0.55(0.33-0.93), IL-10-1082 in allelic 1.19(1.01-1.39) and dominant 1.29(1.02-1.64). In conclusion, serotonin transporter(L/S), IL-10-819(T/C), IL-10-592(C/A), IL-10-1082(G/A), IL-1β-511(C/T), IL-6-174(G/C), and IL-1β+3954 (T/C) polymorphisms are associated with susceptibility to RAS. These variants could be potential predictors of RAS and could be used for the developing clinically effective genetic panel for RAS.
复发性阿弗他口炎（RAS）是最常见的病因不明的口腔溃疡性疾病之一。识别遗传标记可改善RAS的医疗护理和预防。遗传变异的炎症因子与RAS风险相关。因此，本荟萃分析旨在研究RAS中的基因多态性。在Scopus、PubMed和科学网（WOS）上进行了电子文献检索。还手动检查了相关综述的参考文献。纳入截至2020年底的观察性研究。采用固定效应模型和随机效应模型估计比值比（OR）。23项研究中的17种多态性纳入分析。对12种多态性（IL-2 +166、IL-2 -330、IL-4 -590、IL-4 RA1902、IL-6 -597、TNF-α -308、NLRP3(rs4612666、rs10754558)、MMP2 - rs2285053、MMP9 - rs11697325、MMP9 - rs3918242、MMP9 - rs17576、IL-1a -889、IL-10 -819和IL-12 +1188）进行了荟萃分析。对6种多态性（IL-1β -511、IL-1β +3954、IL-6 -174、IL-10 -592、IL-10 -1082和血清素转运体）进行了荟萃分析。IL-10 819在等位基因模型中的结果如下：1.46(1.04 - 2.05)，纯合子模型：1.61(1.08 - 2.39)；血清素转运体在等位基因模型：0.53(0.40 - 0.71)，隐性模型：0.56(0.35 - 0.90)，显性模型：0.35(0.22 - 0.57)，纯合子模型：0.30(0.17 - 0.54)。IL-1β -511在显性模型：0.69(0.50 - 0.95)和超显性模型：0.73(0.55 - 0.96)；IL-1β +3954在等位基因模型：1.25(1.05 - 1.50)，纯合子模型：1.67(1.05 - 2.63)，显性模型：1.26(1.01 - 1.57)；IL-6 -174在显性模型：2.24(1.36 - 3.67)；IL-10 -592在纯合子模型：0.41(0.23 - 0.72)，显性模型：0.55(0.33 - 0.93)；IL-10 -1082在等位基因模型：1.19(1.01 - 1.39)，显性模型：1.29(1.02 - 1.64)。总之，血清素转运体（L/S）、IL-10 -819（T/C）、IL-10 -592（C/A）、IL-10 -1082（G/A）、IL-1β -511（C/T）、IL-6 -174（G/C）和IL-1β +3954（T/C）多态性与RAS易感性相关。这些变异可能是RAS的潜在预测指标，可用于开发针对RAS的临床有效基因检测板。
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