The association between interleukin polymorphism and recurrent aphthous stomatitis: A meta-analysis.

OBJECTIVE

To assess the association between interleukin gene polymorphism and recurrent aphthous stomatitis (RAS).

DESIGNS

Two electronic databases, PubMed and Embase, were utilized to assemble potentially relevant studies meeting the inclusion criteria. A meta-analysis was conducted using Revman 5.3 software (London, UK), and the pooled odds ratio (OR) and 95% confidence interval (CI) were then used to evaluate the strength of the relationship between the gene polymorphisms of IL-1beta(-511C/T), IL-1beta(+3954C/T), IL-6(-174G/C) and IL-10(-1082G/A) and the risk of RAS.

RESULTS

Ten studies were included in the final meta-analysis, with 884 cases and 1104 controls participating. The results demonstrated that the polymorphism of IL-1beta(-511C/T) significantly increased the probability of the development of RAS in Europeans. (T vs. C: OR = 1.35, 95%CI = 1.09-1.67; CC vs. CT + TT: OR = 1.77, 95%CI = 1.24-2.53; CC vs. TT: OR = 1.86, 95%CI = 1.18-2.95). Furthermore, the C allele in IL-1beta(+3954C/T) was determined to be related to the risk of RAS in Americans (C vs. T: OR = 1.52, 95%CI = 1.07-2.17) and the presence of the C gene was considered a risk variant (CC + CT vs. TT: OR = 1.46, 95%CI = 1.01-2.11), but no relationship was found between the polymorphism of IL-10(-1082G/A) and the risk of RAS.

CONCLUSIONS

The meta-analysis suggested that the mutation of IL-1beta(-511C/T) in Europe and IL-1beta(+3954C/T) in America tend to increase the risk of RAS, but the polymorphism of IL-10(-1082G/A) appears to have no association with RAS risk in America. Further study is required to confirm the above conclusions.