Yang Shuo, Zhang Bin, Shi Quan, Liu Jinglong, Xu Juan, Huo Na
Institute of Stomatology, Chinese PLA General Hospital, Beijing, China.
Medicine (Baltimore). 2017 Dec;96(52):e9533. doi: 10.1097/MD.0000000000009533.
Recurrent aphthous stomatitis (RAS) is a common oral disease with unknown etiology. The association between IL-6-174 G/C and IL10-1082 G/A polymorphisms and the risk of RAS remains controversial. Therefore, we conducted this meta-analysis to gain more evidence-based information.
Four online databases, PubMed, Embase, Web of Science, and Cochrane Library, were searched, and the relevant publications were collected. An odds ratio (OR) with a 95% confidence interval (CI) was applied to assess the association of the IL-6-174 G/C and IL10-1082 G/A polymorphisms with RAS susceptibility.
Nine published case-control studies with 779 patients and 1016 controls were collected. The overall analysis proved that the IL10-1082 G/A polymorphism was significantly associated with the risk of RAS in a dominant model (GG + AG vs AA: OR = 1.49, 95% CI = 1.10-2.01, P = .01). A subgroup analysis based on ethnicity revealed significant associations in Asian populations in allelic, heterozygote, and dominant models (G vs A: OR = 1.55, 95% CI = 1.04-2.31, P = .03; AG vs AA: OR = 1.76, 95% CI = 1.16-2.67, P = .01; GG + AG vs AA: OR = 2.04, 95% CI = 1.37-3.03, P = .00). The association in Caucasians and people of mixed ethnicity requires further study. No significant association was detected between the IL-6-174 G/C polymorphism and RAS in any of the genetic models. However, subgroup analysis by ethnicity revealed that the Caucasians were more likely to develop RAS in 4 genetic models (G vs C: OR = 2.36, 95% CI = 1.26-4.41, P = .01; GG vs CC: OR = 7.05, 95% CI = 3.50-14.18, P = .00; GG + CG vs CC: OR = 4.28, 95% CI = 2.17-8.45, P = .00; GG vs CG + CC: OR = 2.59, 95% CI = 1.05-6.41, P = .04). In addition, a significantly decreased risk of RAS susceptibility was found in Asians (CG vs CC: OR = 0.27, 95% CI = 0.07-0.99, P = .049; GG + CG vs CC: OR = 0.27, 95% CI = 0.07-0.98, P = .047).
Our meta-analysis indicated that the IL10-1082 G/A polymorphism is associated with RAS susceptibility, especially in Asians. In contrast, the IL-6-174 G/C polymorphism does not have a statistically significant association with RAS susceptibility. However, it may play a different role during the development of RAS in different ethnicities.
复发性阿弗他口炎（RAS）是一种病因不明的常见口腔疾病。白细胞介素6（IL-6）-174G/C和白细胞介素10（IL10）-1082G/A基因多态性与RAS风险之间的关联仍存在争议。因此，我们进行了这项荟萃分析以获取更多基于证据的信息。
检索了四个在线数据库，即PubMed、Embase、Web of Science和Cochrane图书馆，并收集了相关出版物。应用比值比（OR）及其95%置信区间（CI）来评估IL-6-174G/C和IL10-1082G/A基因多态性与RAS易感性之间的关联。
收集了9项已发表的病例对照研究，共779例患者和1016例对照。总体分析证明，在显性模型中（GG + AG与AA相比：OR = 1.49，95% CI = 1.10 - 2.01，P = 0.01），IL10-1082G/A基因多态性与RAS风险显著相关。基于种族的亚组分析显示，在亚洲人群中，等位基因、杂合子和显性模型均存在显著关联（G与A相比：OR = 1.55，95% CI = 1.04 - 2.31，P = 0.03；AG与AA相比：OR = 1.76，95% CI = 1.16 - 2.67，P = 0.01；GG + AG与AA相比：OR = 2.04，95% CI = 1.37 - 3.03，P = 0.00）。白种人和混血人群中的关联需要进一步研究。在任何遗传模型中，均未检测到IL-6-174G/C基因多态性与RAS之间存在显著关联。然而，按种族进行的亚组分析显示，在4种遗传模型中，白种人患RAS的可能性更大（G与C相比：OR = 2.36, 95% CI = 1.26 - 4.41, P = 0.01；GG与CC相比：OR = 7.05, 95% CI = 3.50 - 14.18, P = 0.00；GG + CG与CC相比：OR = 4.28, 95% CI = 2.17 - 8.45, P = 0.00；GG与CG + CC相比：OR = 2.59, 95% CI = 1.05 - 6.41, P = 0.04）。此外，在亚洲人中发现RAS易感性风险显著降低（CG与CC相比：OR = 0.27, 95% CI = 0.07 - 0.99, P = 0.049；GG + CG与CC相比：OR = 0.27, 95% CI = 0.07 - 0.98, P = 0.047）。
我们的荟萃分析表明，IL10-1082G/A基因多态性与RAS易感性相关，尤其是在亚洲人中。相比之下，IL-6-174G/C基因多态性与RAS易感性无统计学显著关联。然而，它可能在不同种族的RAS发生发展过程中发挥不同作用。
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