Premedical Cource, Yonsei University College of Medicine, Seoul, Republic of Korea.
Department of Preventive Medicine, Gachon University College of Medicine, 38-13, Dokjeom-ro 3beon-gil, Namdong-gu, Incheon, 21565, Republic of Korea.
BMC Psychiatry. 2022 Mar 21;22(1):207. doi: 10.1186/s12888-022-03847-w.
The diagnosis and treatment of cancer are stressful events that could trigger psychological distress in a large number of cancer patients. The aim of this study was to examine the association between gastric cancer and the risk of new onset of depression among South Korean adults.
Data from 12,664 participants aged over 40 years was derived from the National Health Service National Sample Cohort (2002-2013). The case cohort consists of patients who received a diagnosis of gastric cancer between 2002 and 2009, and the corresponding control group was selected through 1:1 propensity score matching (case: 6332, control: 6332). The new onset of depression was considered as the dependent variable. A Cox proportional hazards regression model was built to analyze the associations between variables in consideration.
Individuals with gastric cancer had a higher risk of new onset of depression than those without cancer (hazard ratio [HR] = 1.28, 95% confidence interval [CI] = 1.13-1.45.) Female gastric patients had a higher risk of depression compared to male patients (Female; HR = 1.89, 95% CI = 1.66-2.16, Male; HR = 1.25, 95% CI = 1.10-1.41). Gastric cancer patients in their 60s had the highest risk of new onset of depression compared to other age groups and no cancer group (HR = 1.61, 95% CI = 1.40-1.85). Gastric cancer patients who were previously diagnosed with depression prior to their diagnosis of cancer had a higher risk of new onset of depression than gastric cancer patients without antecedent diagnosis of depression (Past Depression (Yes); HR = 5.17, 95% CI = 4.10-6.51, Past Depression (No); HR = 1.35, CI = 1.21-1.51).
The study identified a significant relationship between gastric cancer and depression among South Korean adults, suggesting that the diagnosis and treatment of gastric cancer increases the risk of new onset of depression, especially among female patients between 60 and 69 years old of high income and living in metropolitan regions. Pre-existing health conditions also appeared to be a risk factor. Thus, in consideration of treatment efficacy and patients' quality of life, the results of the study emphasizes the need for attentive intervention, while distinguishing the most vulnerable groups.
癌症的诊断和治疗是应激事件，可能会引发大量癌症患者的心理困扰。本研究旨在探讨胃癌与韩国成年人新发抑郁症风险之间的关系。
本研究数据来源于年龄在 40 岁以上的 12664 名参与者，来自国家卫生服务全国样本队列（2002-2013 年）。病例队列由 2002 年至 2009 年间诊断为胃癌的患者组成，相应的对照组通过 1:1 倾向评分匹配（病例：6332，对照：6332）。新发抑郁症被视为因变量。建立 Cox 比例风险回归模型来分析所考虑变量之间的关系。
与无癌症患者相比，胃癌患者新发抑郁症的风险更高（风险比[HR] = 1.28，95%置信区间[CI] = 1.13-1.45）。与男性患者相比，女性胃癌患者患抑郁症的风险更高（女性；HR = 1.89，95%CI = 1.66-2.16，男性；HR = 1.25，95%CI = 1.10-1.41）。与其他年龄组和无癌症组相比，60 多岁的胃癌患者新发抑郁症的风险最高（HR = 1.61，95%CI = 1.40-1.85）。与未确诊抑郁症的胃癌患者相比，先前被诊断患有抑郁症的胃癌患者新发抑郁症的风险更高（既往抑郁症（是）；HR = 5.17，95%CI = 4.10-6.51，既往抑郁症（否）；HR = 1.35，CI = 1.21-1.51）。
本研究在韩国成年人中发现了胃癌与抑郁症之间的显著关系，表明胃癌的诊断和治疗增加了新发抑郁症的风险，尤其是在 60-69 岁的高收入、生活在大都市地区的女性患者中。既往健康状况似乎也是一个风险因素。因此，考虑到治疗效果和患者的生活质量，研究结果强调需要进行有针对性的干预，同时区分最脆弱的群体。
