Department of Psychiatry and Behavioural Sciences, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates.
Department of Anatomy, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates.
BMC Psychiatry. 2022 Mar 21;22(1):209. doi: 10.1186/s12888-022-03842-1.
To date, only few studies have investigated ghrelin levels in bipolar disorders, and all have exclusively measured acylated ghrelin, with none investigating total ghrelin (acylated and des-acylated). We aimed to investigate peripheral levels of acylated and total ghrelin in subjects experiencing a manic episode of bipolar disorder.
Peripheral levels of acylated and total ghrelin were measured in hospitalised medicated individuals recovering from a manic episode. Enzyme-linked immunosorbent assays (ELISA) were used to measure ghrelin levels in patients and compared with healthy controls. The relationship between ghrelin levels in bipolar disorder, self-reported hunger measures, demographic and clinical parameters was investigated with correlational analyses.
Twenty-four subjects (15 males, 9 females) recovering from mania and 27 matched healthy controls (13 males, 14 females) were recruited for the study. Mean values of both acylated (187 vs.520 pg/mL) and total ghrelin (396 vs. 648 pg/mL) were significantly reduced in bipolar disorder (p = 0.001). Ghrelin levels correlated positively with markers of illness severity and negatively with prescribed mood stabilizers, second-generation antipsychotics, weight and body mass index.
Peripheral measurements of acylated and total ghrelin were both reduced in bipolar disorder patients compared to healthy controls. Whilst illness severity promotes higher ghrelin levels, pharmacological treatment and weight gain exercise the opposite effect.
迄今为止，仅有少数研究调查了双相情感障碍患者的 ghrelin 水平，且所有研究均专门测量了酰化 ghrelin，而没有研究总 ghrelin（酰化和去酰化）。我们旨在调查经历双相情感障碍躁狂发作的受试者外周血酰化和总 ghrelin 水平。
测量住院接受药物治疗的正在从躁狂发作中恢复的个体的外周血酰化和总 ghrelin 水平。酶联免疫吸附测定（ELISA）用于测量患者和健康对照者的 ghrelin 水平，并进行比较。用相关分析研究双相情感障碍患者的 ghrelin 水平与自我报告的饥饿程度、人口统计学和临床参数之间的关系。
研究纳入了 24 名（15 名男性，9 名女性）从躁狂发作中恢复的受试者和 27 名匹配的健康对照者（13 名男性，14 名女性）。双相情感障碍患者的酰化 ghrelin（187 vs.520 pg/mL）和总 ghrelin（396 vs.648 pg/mL）的平均值均显著降低（p=0.001）。ghrelin 水平与疾病严重程度标志物呈正相关，与所开的心境稳定剂、第二代抗精神病药物、体重和体重指数呈负相关。
与健康对照组相比，双相情感障碍患者的外周血酰化和总 ghrelin 测量值均降低。虽然疾病严重程度会导致 ghrelin 水平升高，但药物治疗和体重增加会产生相反的效果。
