Perna Simone, Spadaccini Daniele, Gasparri Clara, Peroni Gabriella, Infantino Vittoria, Iannello Giancarlo, Riva Antonella, Petrangolini Giovanna, Alalwan Tariq A, Al-Thawadi Salwa, Rondanelli Mariangela
Department of Biology, College of Science, University of Bahrain, Sakhir, Kingdom of Bahrain.
Endocrinology and Nutrition Unit, Azienda di Servizi alla Persona 'Istituto Santa Margherita', University of Pavia, Pavia, Italy.
Nutr Neurosci. 2022 Feb;25(2):336-342. doi: 10.1080/1028415X.2020.1752997. Epub 2020 Apr 15.
This study aimed to analyse the impact of des-acyl and acyl ghrelin (AG) on a wide range of muscular and metabolic markers and in order to discover the possible relationships and interactions of des-acylated ghrelin (DAG) on eating disorders. A total of 88 subjects (64 women and 24 men, with a mean age of 43 years and a mean body mass index (BMI) of 30.20 ± 3.27 kg/m) were enrolled in the cross-sectional study. The findings showed that for each unit of increase of free fat mass index (FFMI), levels of DAG decreased by -41.11 pg/mL ( < 0.05). Moreover, similar associations with DAG were found for insulin ( = -30.67; < 0.001), leptin ( = -0.64; < 0.05), body weight ( = -14.36; < 0.001), and free fat mass (FFM) ( = -30.67; < 0.001). In addition, associations were found between DAG and resting energy expenditure (REE) ( = -0.84; = 0.05) and the binge eating scale (BES) in which a unit increase of the BES score Q3 (depression) correlated with a decrease of DAG levels ( = -9.98; = 0.08). Further, a unit increase of AG/DAG ratio correspond with an increase in body weight ( = 12.20; < 0.05), BMI ( = 4.70; < 0.05) and fat mass ( = 7.30; < 0.05). However, the AG/DAG ratio was not associated with FFMI ( = 2.61; = 0.165) and FFML/BMI ( = -0,064; = 0.625). This study suggests that higher levels of DAG at fasting are indices of poor muscle mass, insulin resistance and depression.
本研究旨在分析去酰基胃饥饿素和酰基胃饥饿素（AG）对一系列肌肉和代谢标志物的影响，以发现去酰基胃饥饿素（DAG）与饮食失调之间可能的关系和相互作用。共有88名受试者（64名女性和24名男性，平均年龄43岁，平均体重指数（BMI）为30.20±3.27kg/m²）参与了这项横断面研究。研究结果表明，游离脂肪质量指数（FFMI）每增加一个单位，DAG水平下降-41.11pg/mL（P<0.05）。此外，胰岛素（r=-30.67；P<0.001）、瘦素（r=-0.64；P<0.05）、体重（r=-14.36；P<0.001）和游离脂肪质量（FFM）（r=-30.67；P<0.001）与DAG也存在类似的关联。此外，还发现DAG与静息能量消耗（REE）（r=-0.84；P=0.05）和暴饮暴食量表（BES）之间存在关联，其中BES评分Q3（抑郁）每增加一个单位与DAG水平下降相关（r=-9.98；P=0.08）。此外，AG/DAG比值每增加一个单位，体重（r=12.20；P<0.05）、BMI（r=4.70；P<0.05）和脂肪量（r=7.30；P<0.05）增加。然而，AG/DAG比值与FFMI（r=2.61；P=0.165）和FFML/BMI（r=-0.064；P=0.625）无关。本研究表明，空腹时较高水平的DAG是肌肉质量差、胰岛素抵抗和抑郁的指标。
